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Detection of Antibody and Antigen for Lassa Virus Nucleoprotein in Monkeys from Southern Nigeria.
Ogunro, Bamidele Nyemike; Olugasa, Babasola Oluseyi; Kayode, Adeyemi; Ishola, Olayinka Olabisi; Kolawole, Oluseyi Noah; Odigie, Eugene Amiewanlen; Happi, Christian.
Afiliación
  • Ogunro BN; Veterinary Teaching Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria.
  • Olugasa BO; Centre for Control and Prevention of Zoonoses, University of Ibadan, Ibadan, Oyo State, Nigeria.
  • Kayode A; Department of Veterinary Public Health and Preventive Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
  • Ishola OO; Centre for Control and Prevention of Zoonoses, University of Ibadan, Ibadan, Oyo State, Nigeria.
  • Kolawole ON; Department of Veterinary Public Health and Preventive Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
  • Odigie EA; African Center for Excellence in Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
  • Happi C; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria.
J Epidemiol Glob Health ; 9(2): 125-127, 2019 06.
Article en En | MEDLINE | ID: mdl-31241870
Lassa fever is a deadly viral haemorrhagic fever caused by Lassa Virus (LASV). Rodents, especially, Mystomys natalensis, are the known reservoirs of LASV and humans are the defined hosts. Monkeys share many illnesses with humans and experimental LASV infections in monkeys are fatal but natural LASV infection of monkeys has not been reported. Serum samples obtained between August 2015 and December 2017 from 62 monkeys belonging to six species in Southern Nigeria were tested for LASV as part of an ongoing surveillance of monkeys in the region for zoonotic pathogens. Commercially available Recombinant LASV (ReLASV) Pan-Lassa enzyme-linked immunosorbent assay (ELISA) test kits (Zalgen Labs, Germantown, MD, USA) were used to detect antibodies (IgG and IgM) and antigen specific for LASV nucleoprotein in the sera. Lassa-fever-specific IgG and IgM, and antigen specific for LASV nucleoprotein were detected in 5/62, 0/62, and 1/62 samples, respectively. The presence of LASV-specific antibodies in the sera suggests natural exposure to the virus, while the presence of LASV antigen may mean that monkeys are carriers of the virus. There is a need to broaden Lassa fever surveillance to include nonhuman primates (NHPs) for their probable role in the epidemiology of the disease.HIGHLIGHTS.• Rodents are the natural reservoirs of Lassa fever virus (LASV) and humans are the defined hosts.• Experimental LASV infections in non-human primates (NHP) are fatal but natural infection of NHP with the virus have not been reported.• We detected antigen and antibody specific for LASV in free-living Monkeys from southern Nigeria which implies that monkeys in the region are naturally exposed to LASV and are probable carriers of the virus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fiebre de Lassa / Anticuerpos Antivirales / Antígenos Virales / Nucleoproteínas Tipo de estudio: Diagnostic_studies Límite: Animals País/Región como asunto: Africa Idioma: En Revista: J Epidemiol Glob Health Año: 2019 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fiebre de Lassa / Anticuerpos Antivirales / Antígenos Virales / Nucleoproteínas Tipo de estudio: Diagnostic_studies Límite: Animals País/Región como asunto: Africa Idioma: En Revista: J Epidemiol Glob Health Año: 2019 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Suiza