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Shielding and stealth effects of zwitterion moieties in double-functionalized silica nanoparticles.
Loiola, Lívia M D; Batista, Marina; Capeletti, Larissa B; Mondo, Gabriela B; Rosa, Rhubia S M; Marques, Rafael E; Bajgelman, Marcio C; Cardoso, Mateus B.
Afiliación
  • Loiola LMD; Brazilian Nanotechnology National Laboratory (LNNano). Brazilian Center for Research in Energy and Materials (CNPEM), Zip Code 13083-970, Campinas, São Paulo, Brazil.
  • Batista M; Brazilian Nanotechnology National Laboratory (LNNano). Brazilian Center for Research in Energy and Materials (CNPEM), Zip Code 13083-970, Campinas, São Paulo, Brazil.
  • Capeletti LB; Brazilian Nanotechnology National Laboratory (LNNano). Brazilian Center for Research in Energy and Materials (CNPEM), Zip Code 13083-970, Campinas, São Paulo, Brazil; Institute of Chemistry, University of Campinas - UNICAMP, P.O. Box 6154, Zip Code 13083-970, Campinas, São Paulo, Brazil.
  • Mondo GB; Brazilian Nanotechnology National Laboratory (LNNano). Brazilian Center for Research in Energy and Materials (CNPEM), Zip Code 13083-970, Campinas, São Paulo, Brazil; Institute of Chemistry, University of Campinas - UNICAMP, P.O. Box 6154, Zip Code 13083-970, Campinas, São Paulo, Brazil.
  • Rosa RSM; Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Zip Code 13083-970, Campinas, São Paulo, Brazil.
  • Marques RE; Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Zip Code 13083-970, Campinas, São Paulo, Brazil.
  • Bajgelman MC; Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Zip Code 13083-970, Campinas, São Paulo, Brazil.
  • Cardoso MB; Brazilian Nanotechnology National Laboratory (LNNano). Brazilian Center for Research in Energy and Materials (CNPEM), Zip Code 13083-970, Campinas, São Paulo, Brazil; Institute of Chemistry, University of Campinas - UNICAMP, P.O. Box 6154, Zip Code 13083-970, Campinas, São Paulo, Brazil. Electronic
J Colloid Interface Sci ; 553: 540-548, 2019 Oct 01.
Article en En | MEDLINE | ID: mdl-31234127
Surface functionalization of silica nanoparticles (SiO2NPs) has been considered as a promising strategy to develop target-specific nanostructures. However, finding a chemical functionalization that can be used as an active targeting moiety while preserving the nanoparticles colloidal stability in biological fluids is still challenging. We present here a dual surface modification strategy for SiO2NPs where a zwitterion (ZW) and a biologically active group (BAG) (amino, mercapto or carboxylic functionalities) are simultaneously grafted on the nanoparticles' surface. The rationale behind this strategy is to generate colloidally stable nanoparticles and avoid the nonspecific protein adsorption due to ZW groups insertion, while the effective interaction with biosystems is guaranteed by the BAGs presence. The biological efficacy was tested against VERO cells, E. coli bacteria and Zika viruses and a similar trend was observed for all tested particles. The desirable "stealth property" to prevent nonspecific protein adhesion also generated a ZW shielding effect of the BAG functionality hindering their proper interaction and activity in cells, bacteria and viruses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Colloid Interface Sci Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Colloid Interface Sci Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos