Lens cholesterol biosynthesis inhibition: A common mechanism of cataract formation in laboratory animals by pharmaceutical products.

Aleo, Michael D; Doshna, Colleen M; Baltrukonis, Daniel; Fortner, Jay H; Drupa, Cynthia A; Navetta, Kimberly A; Fritz, Carol A; Potter, David M; Verdugo, Maria E; Beierschmitt, William P

Aleo, Michael D; Doshna, Colleen M; Baltrukonis, Daniel; Fortner, Jay H; Drupa, Cynthia A; Navetta, Kimberly A; Fritz, Carol A; Potter, David M; Verdugo, Maria E; Beierschmitt, William P.

Afiliación

Aleo MD; Drug Safety R&D, Groton, Connecticut.
Doshna CM; Drug Safety R&D, Groton, Connecticut.
Baltrukonis D; Drug Safety R&D, Groton, Connecticut.
Fortner JH; Comparative Medicine, Pfizer Worldwide Research and Development, Groton, Connecticut.
Drupa CA; Drug Safety R&D, Groton, Connecticut.
Navetta KA; Drug Safety R&D, Groton, Connecticut.
Fritz CA; Drug Safety R&D, Groton, Connecticut.
Potter DM; Drug Safety R&D, Groton, Connecticut.
Verdugo ME; Drug Safety R&D, Groton, Connecticut.
Beierschmitt WP; Drug Safety R&D, Groton, Connecticut.

J Appl Toxicol ; 39(9): 1348-1361, 2019 09.

Article en En | MEDLINE | ID: mdl-31231834

Asunto(s)

Catarata/inducido químicamente; Colesterol/biosíntesis; Colesterol/toxicidad; Inhibidores Enzimáticos/toxicidad; Cristalino/efectos de los fármacos; Cristalino/metabolismo; Tiazolidinedionas/toxicidad; Animales; Animales de Laboratorio; Catarata/metabolismo; Perros; Femenino; Masculino; Preparaciones Farmacéuticas; Ratas; Ratas Sprague-Dawley

Palabras clave

5-LO inhibitors; cataract; cholesterol biosynthesis; dopamine receptor antagonists, subtype 4 (D4); explant rat lens; neuronal nitric oxide synthase (nNOS) inhibitor; peroxisome proliferator-activated receptor-gamma (PPAR-Î³); sorbitol dehydrogenase inhibitor (SDI); squalene synthetase inhibitor (SSI); stearoyl-CoA desaturase-1 (SCD-1) inhibitor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catarata / Colesterol / Tiazolidinedionas / Inhibidores Enzimáticos / Cristalino Límite: Animals Idioma: En Revista: J Appl Toxicol Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido

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