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Galleria mellonella as an infection model for the multi-host pathogen Streptococcus agalactiae reflects hypervirulence of strains associated with human invasive disease.
Six, Anne; Krajangwong, Sakranmanee; Crumlish, Margaret; Zadoks, Ruth N; Walker, Daniel.
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  • Six A; a Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences , University of Glasgow , Glasgow , UK.
  • Krajangwong S; a Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences , University of Glasgow , Glasgow , UK.
  • Crumlish M; b Institute of Aquaculture , University of Stirling , Stirling , UK.
  • Zadoks RN; c Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences , University of Glasgow , Glasgow , UK.
  • Walker D; a Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences , University of Glasgow , Glasgow , UK.
Virulence ; 10(1): 600-609, 2019 12.
Article en En | MEDLINE | ID: mdl-31230520
Streptococcus agalactiae, or group B Streptococcus (GBS), infects diverse hosts including humans and economically important species such as cattle and fishes. In the context of human health, GBS is a major cause of neonatal infections and an emerging cause of invasive disease in adults and of foodborne disease in Southeast Asia. Here we show that GBS is able to establish a systemic infection in Galleria mellonella larvae that is associated with extensive bacterial replication and dose-dependent larval survival. This infection model is suitable for use with GBS isolates from both homeothermic and poikilothermic hosts. Hypervirulent sequence types (ST) associated with invasive human disease in neonates (ST17) or adults (ST283) show increased virulence in this model, indicating it may be useful in studying GBS virulence determinants, albeit with limitations for some host-specific virulence factors. In addition, we demonstrate that larval survival can be afforded by antibiotic treatment and so the model may also be useful in the development of novel anti-GBS strategies. The use of G. mellonella in GBS research has the potential to provide a low-cost infection model that could reduce the number of vertebrates used in the study of GBS infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Streptococcus agalactiae / Modelos Animales de Enfermedad / Lepidópteros Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Virulence Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Streptococcus agalactiae / Modelos Animales de Enfermedad / Lepidópteros Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Virulence Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos