Structural basis for recognition and ring-cleavage of the Pseudomonas quinolone signal (PQS) by AqdC, a mycobacterial dioxygenase of the &#945;/ß-hydrolase fold family.

Wullich, Sandra C; Kobus, Stefanie; Wienhold, Max; Hennecke, Ulrich; Smits, Sander H J; Fetzner, Susanne

Structural basis for recognition and ring-cleavage of the Pseudomonas quinolone signal (PQS) by AqdC, a mycobacterial dioxygenase of the α/ß-hydrolase fold family.

Wullich, Sandra C; Kobus, Stefanie; Wienhold, Max; Hennecke, Ulrich; Smits, Sander H J; Fetzner, Susanne.

Afiliación

Wullich SC; Institute for Molecular Microbiology and Biotechnology, University of Münster, Corrensstraße 3, 48149 Münster, Germany. Electronic address: wullich@wwu.de.
Kobus S; Center for Structural Studies, Heinrich-Heine-University, Universitätsstraße 1, 40225 Düsseldorf, Germany. Electronic address: stefanie.kobus@uni-duesseldorf.de.
Wienhold M; Organic Chemistry Institute, University of Münster, Corrensstraße 40, 48149 Münster, Germany. Electronic address: m_wien13@uni-muenster.de.
Hennecke U; Organic Chemistry Institute, University of Münster, Corrensstraße 40, 48149 Münster, Germany; Organic Chemistry Research Group, Department of Chemistry and Department of Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussel, Belgium. Electronic address: ulrich.hennecke@uni-m
Smits SHJ; Center for Structural Studies, Heinrich-Heine-University, Universitätsstraße 1, 40225 Düsseldorf, Germany; Institute of Biochemistry, Heinrich-Heine-University, Universitätsstraße 1, 40225 Düsseldorf, Germany. Electronic address: sander.smits@hhu.de.
Fetzner S; Institute for Molecular Microbiology and Biotechnology, University of Münster, Corrensstraße 3, 48149 Münster, Germany. Electronic address: fetzner@uni-muenster.de.

J Struct Biol ; 207(3): 287-294, 2019 09 01.

Article en En | MEDLINE | ID: mdl-31228546

Asunto(s)

Dioxigenasas/química; Hidrolasas/química; Pseudomonas aeruginosa/metabolismo; Quinolonas/química; Cristalografía por Rayos X; Dioxigenasas/genética; Dioxigenasas/metabolismo; Regulación Bacteriana de la Expresión Génica; Enlace de Hidrógeno; Hidrolasas/genética; Hidrolasas/metabolismo; Cinética; Modelos Moleculares; Mutación; Mycobacterium/enzimología; Mycobacterium/genética; Filogenia; Unión Proteica; Conformación Proteica; Pseudomonas aeruginosa/genética; Quinolonas/metabolismo; Especificidad por Sustrato

Palabras clave

Alpha/beta hydrolase fold; Catalytic triad; Dioxygenase; Pseudomonas aeruginosa; Pseudomonas quinolone signal; Quorum sensing

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Quinolonas / Dioxigenasas / Hidrolasas Tipo de estudio: Prognostic_studies Idioma: En Revista: J Struct Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos

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