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Toll-like receptor 5-mediated IL-17C expression in intestinal epithelial cells enhances epithelial host defense against F4+ ETEC infection.
Luo, Yu; Xu, Jia; Zhang, Chaoying; Jiang, Chunyan; Ma, Yanfeng; He, Haijian; Wu, Yuan; Devriendt, Bert; Cox, Eric; Zhang, Hongbin.
Afiliación
  • Luo Y; Animal Medical Testing Center, Department of Animal Production, Faculty of Agricultural & Biological Engineering, Jinhua Polytechnic, Jinhua, China. luoyu@jhc.cn.
  • Xu J; Animal Medical Testing Center, Department of Animal Production, Faculty of Agricultural & Biological Engineering, Jinhua Polytechnic, Jinhua, China.
  • Zhang C; Animal Medical Testing Center, Department of Animal Production, Faculty of Agricultural & Biological Engineering, Jinhua Polytechnic, Jinhua, China.
  • Jiang C; Animal Medical Testing Center, Department of Animal Production, Faculty of Agricultural & Biological Engineering, Jinhua Polytechnic, Jinhua, China.
  • Ma Y; Animal Medical Testing Center, Department of Animal Production, Faculty of Agricultural & Biological Engineering, Jinhua Polytechnic, Jinhua, China.
  • He H; Animal Medical Testing Center, Department of Animal Production, Faculty of Agricultural & Biological Engineering, Jinhua Polytechnic, Jinhua, China.
  • Wu Y; Animal Medical Testing Center, Department of Animal Production, Faculty of Agricultural & Biological Engineering, Jinhua Polytechnic, Jinhua, China.
  • Devriendt B; Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
  • Cox E; Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
  • Zhang H; Animal Medical Testing Center, Department of Animal Production, Faculty of Agricultural & Biological Engineering, Jinhua Polytechnic, Jinhua, China.
Vet Res ; 50(1): 48, 2019 Jun 20.
Article en En | MEDLINE | ID: mdl-31221216
Enterotoxigenic Escherichia coli (ETEC) are an important cause of post-weaning diarrhea (PWD) in piglets. The IL-17 cytokine family is well known to play important roles in the host defense against bacterial infections at the mucosa. Previously, we reported the potential role of IL-17A in clearing an ETEC infection in piglets. IL-17C, another member of the IL-17 family, is highly expressed in the intestinal epithelium, however, its role during an ETEC infection is still unclear. In this study, we demonstrate that F4+ ETEC induce IL-17C mRNA and protein expression in intestinal tissues as well as in porcine intestinal epithelial cells (IPEC-J2). This IL-17C production is largely dependent on TLR5 signaling in IPEC-J2 cells. Both F4+ ETEC infection and exogenous IL-17C increased the expression of antimicrobial peptides and tight junction proteins, such as porcine beta-defensin (pBD)-2, claudin-1, claudin-2 and occludin in IPEC-J2 cells. Taken together, our data demonstrate that TLR5-mediated IL-17C expression in intestinal epithelial cells enhances mucosal host defense responses in a unique autocrine/paracrine manner in the intestinal epithelium against ETEC infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Porcinos / Interleucina-17 / Infecciones por Escherichia coli / Receptor Toll-Like 5 / Escherichia coli Enterotoxigénica Límite: Animals Idioma: En Revista: Vet Res Asunto de la revista: MEDICINA VETERINARIA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Porcinos / Interleucina-17 / Infecciones por Escherichia coli / Receptor Toll-Like 5 / Escherichia coli Enterotoxigénica Límite: Animals Idioma: En Revista: Vet Res Asunto de la revista: MEDICINA VETERINARIA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido