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Isolated Langerhans Cell Histiocytosis of the Lacrimal Gland in Conjunction With Mucosa-Associated Lymphoid Tissue Lymphoma and Elevated IgG4 Plasma Cells.
Peck, Travis; Bagg, Adam; Zhang, Xiaoming; Armstrong, Blair; Eagle, Ralph C; Milman, Tatyana.
Afiliación
  • Peck T; Department of Ophthalmology, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.
  • Bagg A; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, U.S.A.
  • Zhang X; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, U.S.A.
  • Armstrong B; Department of Ophthalmology, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.
  • Eagle RC; Department of Ophthalmology, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.
  • Milman T; Pathology Department, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.
Ophthalmic Plast Reconstr Surg ; 35(4): e92-e94, 2019.
Article en En | MEDLINE | ID: mdl-31219941
Langerhans cell histiocytosis (LCH) is a clonal neoplastic proliferation of Langerhans-type cells. Orbital LCH is infrequent, typically manifesting as an isolated lytic bony lesion with an adjacent soft tissue mass in a child. Isolated lacrimal gland involvement by LCH is extremely rare, with only 2 previously reported cases. The authors describe a 37-year-old woman with a 6-month history of painless right upper eyelid swelling and diffuse right lacrimal gland enlargement without bony changes on computed tomography scan. Excisional biopsy of the lacrimal gland demonstrated concurrent LCH, extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, and increased IgG4-expressing plasma cells. Work-up was negative for systemic hematolymphoid malignancy and IgG4-related disease. This case illustrates the association between LCH, mucosa-associated lymphoid tissue lymphoma, and elevated IgG4 plasma cells in the lacrimal gland, and we review the emerging theories proposed to explain this phenomenon.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Plasmáticas / Inmunoglobulina G / Histiocitosis de Células de Langerhans / Linfoma de Células B de la Zona Marginal / Aparato Lagrimal / Enfermedades del Aparato Lagrimal Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Female / Humans Idioma: En Revista: Ophthalmic Plast Reconstr Surg Asunto de la revista: OFTALMOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Plasmáticas / Inmunoglobulina G / Histiocitosis de Células de Langerhans / Linfoma de Células B de la Zona Marginal / Aparato Lagrimal / Enfermedades del Aparato Lagrimal Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Female / Humans Idioma: En Revista: Ophthalmic Plast Reconstr Surg Asunto de la revista: OFTALMOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos