Angiopoietin-like 2 upregulation promotes human chondrocyte injury via NF-&#954;B and p38/MAPK signaling pathway.

Shan, Wenshan; Cheng, Chao; Huang, Wei; Ding, Zhenfei; Luo, Sha; Cui, Guanjun; Lu, Wei; Liu, Fuen; Xu, JieGou; He, Wei; Yin, Zongsheng

Angiopoietin-like 2 upregulation promotes human chondrocyte injury via NF-κB and p38/MAPK signaling pathway.

Shan, Wenshan; Cheng, Chao; Huang, Wei; Ding, Zhenfei; Luo, Sha; Cui, Guanjun; Lu, Wei; Liu, Fuen; Xu, JieGou; He, Wei; Yin, Zongsheng.

Afiliación

Shan W; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
Cheng C; Department of Orthopaedics, The Fourth Affiliated Hospital of Anhui Medical University, 372#Tun Xi Road, Hefei, 230032, Anhui, China.
Huang W; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
Ding Z; Division of Life Sciences and Medicine, Department of Orthopaedics, The First Affiliated Hospital of USTC, University of Science and Technology of China, 17#Lu Jiang Road, Hefei, 230001, Anhui, China.
Luo S; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
Cui G; School of Basic Medical Science, and the First Clinical Medical College, Anhui Medical University, 81# Mei Shan Road, Hefei, 230032, Anhui, China.
Lu W; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
Liu F; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
Xu J; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
He W; School of Basic Medical Science, and the First Clinical Medical College, Anhui Medical University, 81# Mei Shan Road, Hefei, 230032, Anhui, China. xujiegou@ahmu.edu.cn.
Yin Z; School of Basic Medical Science, and the First Clinical Medical College, Anhui Medical University, 81# Mei Shan Road, Hefei, 230032, Anhui, China. weihe@ahmu.edu.cn.

J Bone Miner Metab ; 37(6): 976-986, 2019 Nov.

Article en En | MEDLINE | ID: mdl-31214838

Asunto(s)

Proteínas Similares a la Angiopoyetina/genética; Condrocitos/metabolismo; Condrocitos/patología; Interleucina-1beta/farmacología; Sistema de Señalización de MAP Quinasas; FN-kappa B/metabolismo; Regulación hacia Arriba/genética; Proteína 2 Similar a la Angiopoyetina; Proteínas Similares a la Angiopoyetina/metabolismo; Cartílago/efectos de los fármacos; Cartílago/metabolismo; Cartílago/patología; Células Cultivadas; Condrocitos/efectos de los fármacos; Colágeno Tipo II/metabolismo; Humanos; Integrina alfa5beta1/metabolismo; Interleucina-6/biosíntesis; Sistema de Señalización de MAP Quinasas/efectos de los fármacos; Metaloproteinasas de la Matriz/metabolismo; Osteoartritis/metabolismo; Osteoartritis/patología; Regulación hacia Arriba/efectos de los fármacos

Palabras clave

ANGPTL2; ECM degradation; Inflammation mediators production; Osteoarthritis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación hacia Arriba / FN-kappa B / Condrocitos / Sistema de Señalización de MAP Quinasas / Interleucina-1beta / Proteínas Similares a la Angiopoyetina Límite: Humans Idioma: En Revista: J Bone Miner Metab Asunto de la revista: METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Japón

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