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Neutrophil-to-Lymphocyte Ratio as a Predictor of Invasive Carcinoma in Patients With Intraductal Papillary Mucinous Neoplasms of the Pancreas.
McIntyre, Caitlin A; Pulvirenti, Alessandra; Lawrence, Sharon A; Seier, Kenneth; Gonen, Mithat; Balachandran, Vinod P; Kingham, T Peter; DʼAngelica, Michael I; Drebin, Jeffrey A; Jarnagin, William R; Allen, Peter J.
Afiliación
  • McIntyre CA; From the Department of Surgery, Hepatopancreatobiliary Service, and.
  • Pulvirenti A; From the Department of Surgery, Hepatopancreatobiliary Service, and.
  • Lawrence SA; From the Department of Surgery, Hepatopancreatobiliary Service, and.
  • Seier K; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering, New York, NY.
  • Gonen M; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering, New York, NY.
  • Balachandran VP; From the Department of Surgery, Hepatopancreatobiliary Service, and.
  • Kingham TP; From the Department of Surgery, Hepatopancreatobiliary Service, and.
  • DʼAngelica MI; From the Department of Surgery, Hepatopancreatobiliary Service, and.
  • Drebin JA; From the Department of Surgery, Hepatopancreatobiliary Service, and.
  • Jarnagin WR; From the Department of Surgery, Hepatopancreatobiliary Service, and.
  • Allen PJ; From the Department of Surgery, Hepatopancreatobiliary Service, and.
Pancreas ; 48(6): 832-836, 2019 07.
Article en En | MEDLINE | ID: mdl-31210665
OBJECTIVES: Preoperative determination of the grade of dysplasia in intraductal papillary mucinous neoplasms (IPMNs) is necessary for optimal management. Previous data have suggested that serum neutrophil-to-lymphocyte ratio (NLR) can predict invasive disease in patients with IPMN. METHODS: A prospectively maintained database was queried for consecutive patients who underwent resection of IPMN. Exclusion criteria included recent diagnosis of cancer, immunosuppression, and infection or jaundice within 1 month of operation. A complete blood count with differential within 30 days of operation was used to calculate NLR. RESULTS: Within the study period, 446 patients underwent resection for IPMN, and 348 patients (78%) met the inclusion criteria. Low-grade dysplasia was present in 60 patients (17%), 137 patients (39%) had intermediate-grade dysplasia, 76 (22%) had high-grade dysplasia, and 75 (22%) had invasive carcinoma. A higher NLR was associated with invasive carcinoma as compared with noninvasive disease (3.00 vs 2.68, P = 0.039). There was no difference in NLR between patients with high-risk (invasive and high-grade) and low-risk (low-grade and intermediate-grade) lesions (2.80 vs 2.71, P > 0.95). CONCLUSIONS: Neutrophil-to-lymphocyte ratio was significantly higher in patients with IPMN-associated invasive carcinoma as compared with patients with noninvasive disease; however, NLR was not helpful in differentiating between high- and low-grade lesions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Páncreas / Pancreatectomía / Linfocitos / Neoplasias Intraductales Pancreáticas / Neutrófilos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Pancreas Asunto de la revista: GASTROENTEROLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Páncreas / Pancreatectomía / Linfocitos / Neoplasias Intraductales Pancreáticas / Neutrófilos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Pancreas Asunto de la revista: GASTROENTEROLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos