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Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness: a twin study.
Szily, Marcell; Tarnoki, Adam D; Tarnoki, David L; Kovacs, Daniel T; Forgo, Bianka; Lee, Jooyeon; Kim, Eunae; Sung, Joohon; Kunos, Laszlo; Meszaros, Martina; Muller, Veronika; Bikov, Andras.
Afiliación
  • Szily M; Department of Radiology, Semmelweis University, 78/A Ulloi street, 1082, Budapest, Hungary.
  • Tarnoki AD; Department of Radiology, Semmelweis University, 78/A Ulloi street, 1082, Budapest, Hungary. tarnoki2@gmail.com.
  • Tarnoki DL; Department of Radiology, Semmelweis University, 78/A Ulloi street, 1082, Budapest, Hungary.
  • Kovacs DT; Department of Radiology, Semmelweis University, 78/A Ulloi street, 1082, Budapest, Hungary.
  • Forgo B; Department of Radiology, Semmelweis University, 78/A Ulloi street, 1082, Budapest, Hungary.
  • Lee J; Complex Disease and Genome Epidemiology Branch, Department of Public Health Science, School of Public Health, Seoul National University, Seoul, Republic of Korea.
  • Kim E; Complex Disease and Genome Epidemiology Branch, Department of Public Health Science, School of Public Health, Seoul National University, Seoul, Republic of Korea.
  • Sung J; Complex Disease and Genome Epidemiology Branch, Department of Public Health Science, School of Public Health, Seoul National University, Seoul, Republic of Korea.
  • Kunos L; Department of Pulmonology, Semmelweis University, Budapest, Hungary.
  • Meszaros M; Department of Pulmonology, Semmelweis University, Budapest, Hungary.
  • Muller V; Department of Pulmonology, Semmelweis University, Budapest, Hungary.
  • Bikov A; Department of Pulmonology, Semmelweis University, Budapest, Hungary.
Respir Res ; 20(1): 125, 2019 Jun 17.
Article en En | MEDLINE | ID: mdl-31208424
BACKGROUND: Obstructive sleep apnoea (OSA) is one of the major sources of the excessive daily sleepiness, cognitive dysfunction, and it increases cardiovascular morbidity and mortality. Previous studies suggested a possible genetic influence, based on questionnaires but no objective genetic study was conducted to understand the exact variance underpinned by genetic factors. METHODS: Seventy-one Hungarian twin pairs involved from the Hungarian Twin Registry (48 monozygotic, MZ and 23 dizygotic, DZ pairs, mean age 51 ± 15 years) underwent overnight polysomnography (Somnoscreen Plus Tele PSG, Somnomedics GMBH, Germany). Apnoea hypopnea index (AHI), respiratory disturbance index (RDI) and oxygen desaturation index (ODI) were registered. Daytime sleepiness was measured with the Epworth Sleepiness Scale (ESS). Bivariate heritability analysis was applied. RESULTS: The prevalence of OSA was 41% in our study population. The heritability of the AHI, ODI and RDI ranged between 69% and 83%, while the OSA, defined by an AHI ≥5/h, was itself 73% heritable. The unshared environmental component explained the rest of the variance between 17% and 31%. Daytime sleepiness was mostly determined by the environment, and the variance was influenced in 34% by the additive genetic factors. These associations were present after additional adjustment for body mass index. CONCLUSION: OSA and the indices of OSA severity are heritable, while daytime sleepiness is mostly influenced by environmental factors. Further studies should elucidate whether close relatives of patients with OSA may benefit from early family risk based screening.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Apnea Obstructiva del Sueño / Enfermedades en Gemelos / Somnolencia / Trastornos de Somnolencia Excesiva Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Respir Res Año: 2019 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Apnea Obstructiva del Sueño / Enfermedades en Gemelos / Somnolencia / Trastornos de Somnolencia Excesiva Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Respir Res Año: 2019 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Reino Unido