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Antigenicity and immune correlate assessment of seven Plasmodium falciparum antigens in a longitudinal infant cohort from northern Ghana.
Kusi, Kwadwo Asamoah; Aguiar, Joao; Kumordjie, Selassie; Aggor, Felix; Bolton, Jessica; Renner, Andrea; Kyei-Baafour, Eric; Puplampu, Naiki; Belmonte, Maria; Dodoo, Daniel; Gyan, Ben Adu; Ofori, Michael Fokuo; Oduro, Abraham Rex; Atuguba, Frank; Koram, Kwadwo Ansah; Adams, Nehkonti; Letizia, Andrew; Villasante, Eileen; Sedegah, Martha.
Afiliación
  • Kusi KA; Immunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana. akusi@noguchi.ug.edu.gh.
  • Aguiar J; Malaria Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA.
  • Kumordjie S; Immunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
  • Aggor F; Immunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
  • Bolton J; University of Pittsburgh School of Medicine, Division of Rheumatology and Clinical Immunology, 200 Lothrop St., SBST 737, Pittsburgh, PA, 15213, USA.
  • Renner A; Malaria Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA.
  • Kyei-Baafour E; Malaria Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA.
  • Puplampu N; Congressionally Directed Medical Research Programs (CDMRP) The United States Army Medical Research and Materiel Command (USAMRMC), 1054 Patchel Street, Fort Detrick, MD, 21702, USA.
  • Belmonte M; Immunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
  • Dodoo D; US Naval Medical Research Unit No. 3, Ghana Detachment, Accra, Ghana.
  • Gyan BA; Malaria Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA.
  • Ofori MF; Immunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
  • Oduro AR; Immunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
  • Atuguba F; Immunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
  • Koram KA; Navrongo Health Research Centre, Ghana Health Service, Navrongo, Ghana.
  • Adams N; Navrongo Health Research Centre, Ghana Health Service, Navrongo, Ghana.
  • Letizia A; Epidemiology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
  • Villasante E; US Naval Medical Research Unit No. 3, Ghana Detachment, Accra, Ghana.
  • Sedegah M; Navy Medicine Professional Development Center, Academic Programs Directorate, 8955 Wood Road, Bldg 1, Bethesda, MD, 20889, USA.
Sci Rep ; 9(1): 8621, 2019 06 13.
Article en En | MEDLINE | ID: mdl-31197225
The current global malaria control and elimination agenda requires development of additional effective disease intervention tools. Discovery and characterization of relevant parasite antigens is important for the development of new diagnostics and transmission monitoring tools and for subunit vaccine development. This study assessed the natural antibody response profile of seven novel Plasmodium falciparum pre-erythrocytic antigens and their potential association with protection against clinical malaria. Antigen-specific antibody levels in plasma collected at six time points from a longitudinal cohort of one-to-five year old children resident in a seasonal malaria transmission area of northern Ghana were assessed by ELISA. Antibody levels were compared between parasite-positive and parasite-negative individuals and the association of antibody levels with malaria risk assessed using a regression model. Plasma antibody levels against five of the seven antigens were significantly higher in parasite-positive children compared to parasite-negative children, especially during low transmission periods. None of the antigen-specific antibodies showed an association with protection against clinical malaria. The study identified five of the seven antigens as markers of exposure to malaria, and these will have relevance for the development of disease diagnostic and monitoring tools. The vaccine potential of these antigens requires further assessment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Malaria Falciparum / Antígenos de Protozoos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child, preschool / Humans / Infant País/Región como asunto: Africa Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Ghana Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Malaria Falciparum / Antígenos de Protozoos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child, preschool / Humans / Infant País/Región como asunto: Africa Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Ghana Pais de publicación: Reino Unido