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A Predictive Model Assessing Genetic Susceptibility Risk at Workplace.
Chiarella, Pieranna; Capone, Pasquale; Carbonari, Damiano; Sisto, Renata.
Afiliación
  • Chiarella P; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL Research, Via Fontana Candida 1, 00078 Monteporzio Catone, Rome, Italy. p.chiarella@inail.it.
  • Capone P; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL Research, Via Fontana Candida 1, 00078 Monteporzio Catone, Rome, Italy. p.capone@inail.it.
  • Carbonari D; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL Research, Via Fontana Candida 1, 00078 Monteporzio Catone, Rome, Italy. d.carbonari@inail.it.
  • Sisto R; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL Research, Via Fontana Candida 1, 00078 Monteporzio Catone, Rome, Italy. r.sisto@inail.it.
Int J Environ Res Public Health ; 16(11)2019 06 05.
Article en En | MEDLINE | ID: mdl-31195756
(1) Background: The study of susceptibility biomarkers in the immigrant workforce integrated into the social tissue of European host countries is always a challenge, due to high individual heterogeneity and the admixing of different ethnicities in the same workplace. These workers having distinct cultural backgrounds, beliefs, diets, and habits, as well as a poor knowledge of the foreign language, may feel reluctant to donate their biological specimens for the biomonitoring research studies. (2) Methods: A model predicting ethnicity-specific susceptibility based on principal component analysis has been conceived, using the genotype frequency of the investigated populations available in publicly accessible databases. (3) Results: Correlations among ethnicities and between ethnic and polymorphic genes have been found, and low/high-risk profiles have been identified as valuable susceptibility biomarkers. (4) Conclusions: In the absence of workers' consent or access to blood genotyping, ethnicity represents a good indicator of the subject's genotype. This model, associating ethnicity-specific genotype frequency with the susceptibility biomarkers involved in the metabolism of toxicants, may replace genotyping, ensuring the necessary safety and health conditions of workers assigned to hazardous jobs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Etnicidad / Lugar de Trabajo / Predisposición Genética a la Enfermedad / Modelos Genéticos Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Int J Environ Res Public Health Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Etnicidad / Lugar de Trabajo / Predisposición Genética a la Enfermedad / Modelos Genéticos Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Int J Environ Res Public Health Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza