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PTX3 Intercepts Vascular Inflammation in Systemic Immune-Mediated Diseases.
Ramirez, Giuseppe A; Rovere-Querini, Patrizia; Blasi, Miriam; Sartorelli, Silvia; Di Chio, Maria Chiara; Baldini, Mattia; De Lorenzo, Rebecca; Bozzolo, Enrica P; Leone, Roberto; Mantovani, Alberto; Manfredi, Angelo A; Tombetti, Enrico.
Afiliación
  • Ramirez GA; Università Vita-Salute San Raffaele, Milan, Italy.
  • Rovere-Querini P; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Blasi M; Division of Immunology, Transplantation and Infectious Immunity, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Sartorelli S; Università Vita-Salute San Raffaele, Milan, Italy.
  • Di Chio MC; Division of Immunology, Transplantation and Infectious Immunity, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Baldini M; Università Vita-Salute San Raffaele, Milan, Italy.
  • De Lorenzo R; Division of Immunology, Transplantation and Infectious Immunity, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Bozzolo EP; Università Vita-Salute San Raffaele, Milan, Italy.
  • Leone R; Università Vita-Salute San Raffaele, Milan, Italy.
  • Mantovani A; Università Vita-Salute San Raffaele, Milan, Italy.
  • Manfredi AA; Division of Immunology, Transplantation and Infectious Immunity, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Tombetti E; Università Vita-Salute San Raffaele, Milan, Italy.
Front Immunol ; 10: 1135, 2019.
Article en En | MEDLINE | ID: mdl-31191526
PTX3 is a prototypic soluble pattern recognition receptor, expressed at sites of inflammation and involved in regulation of the tissue homeostasis. PTX3 systemic levels increase in many (but not all) immune-mediated inflammatory conditions. Research on PTX3 as a biomarker has so far focused on single diseases. Here, we performed a multi-group comparative study with the aim of identifying clinical and pathophysiological phenotypes associated with PTX3 release. PTX3 concentration was measured by ELISA in the plasma of 366 subjects, including 96 patients with giant cell arteritis (GCA), 42 with Takayasu's arteritis (TA), 10 with polymyalgia rheumatica (PMR), 63 with ANCA-associated systemic small vessel vasculitides (AAV), 55 with systemic lupus erythematosus (SLE), 21 with rheumatoid arthritis (RA) and 79 healthy controls (HC). Patients with SLE, AAV, TA and GCA, but not patients with RA and PMR, had higher PTX3 levels than HC. PTX3 concentration correlated with disease activity, acute phase reactants and prednisone dose. It was higher in females, in patients with recent-onset disease and in those with previous or current active vasculitis at univariate analysis. Active small- or large- vessel vasculitis were the main independent variables influencing PTX3 levels at multivariate analysis. High levels of PTX3 in the blood can contribute to identify an increased risk of vascular involvement in patients with systemic immune-mediated diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Vasculitis / Proteína C-Reactiva / Componente Amiloide P Sérico Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Immunol Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Vasculitis / Proteína C-Reactiva / Componente Amiloide P Sérico Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Immunol Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza