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MED25 connects enhancer-promoter looping and MYC2-dependent activation of jasmonate signalling.
Wang, Hang; Li, Shuyu; Li, Yan'an; Xu, Yiran; Wang, Yunhao; Zhang, Ruoxi; Sun, Wenjing; Chen, Qian; Wang, Xiu-Jie; Li, Chuanyou; Zhao, Jiuhai.
Afiliación
  • Wang H; State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, China.
  • Li S; State Key Laboratory of Plant Genomics, National Centre for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
  • Li Y; State Key Laboratory of Plant Genomics, National Centre for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
  • Xu Y; State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, China.
  • Wang Y; Key Laboratory of Genetics Network Biology, Collaborative Innovation Center of Genetics and Development, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
  • Zhang R; State Key Laboratory of Plant Genomics, National Centre for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
  • Sun W; State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, China.
  • Chen Q; State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, China.
  • Wang XJ; Key Laboratory of Genetics Network Biology, Collaborative Innovation Center of Genetics and Development, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
  • Li C; State Key Laboratory of Plant Genomics, National Centre for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. cyli@genetics.ac.cn.
  • Zhao J; University of Chinese Academy of Sciences, Beijing, China. cyli@genetics.ac.cn.
Nat Plants ; 5(6): 616-625, 2019 06.
Article en En | MEDLINE | ID: mdl-31182849
The lipid-derived hormone jasmonate (JA) regulates plant immunity and adaptive growth by triggering a genome-wide transcriptional programme. In Arabidopsis thaliana, JA-triggered transcriptional programming is largely orchestrated by the master transcription factor MYC2. The function of MYC2 is dependent on its physical interaction with the MED25 subunit of the Mediator transcriptional co-activator complex. Here we report the identification of JA enhancers (JAEs) through profiling the occupancy pattern of MYC2 and MED25. JA regulates the dynamic chromatin looping between JAEs and their promoters in a MED25-dependent manner, while MYC2 auto-regulates itself through JAEs. Interestingly, the JAE of the MYC2 locus (named ME2) positively regulates MYC2 expression during short-term JA responses but negatively regulates it during constant JA responses. We demonstrate that new gene editing tools open up new avenues to elucidate the in vivo function of enhancers. Our work provides a paradigm for functional study of plant enhancers in the regulation of specific physiological processes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Transducción de Señal / Arabidopsis / Ciclopentanos / Proteínas de Arabidopsis / Factores de Transcripción Básicos con Cremalleras de Leucinas y Motivos Hélice-Asa-Hélice / Oxilipinas Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Plants Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Transducción de Señal / Arabidopsis / Ciclopentanos / Proteínas de Arabidopsis / Factores de Transcripción Básicos con Cremalleras de Leucinas y Motivos Hélice-Asa-Hélice / Oxilipinas Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Plants Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido