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Body fat distribution on computed tomography imaging and prostate cancer risk and mortality in the AGES-Reykjavik study.
Dickerman, Barbra A; Torfadottir, Johanna E; Valdimarsdottir, Unnur A; Giovannucci, Edward; Wilson, Kathryn M; Aspelund, Thor; Tryggvadottir, Laufey; Sigurdardottir, Lara G; Harris, Tamara B; Launer, Lenore J; Gudnason, Vilmundur; Markt, Sarah C; Mucci, Lorelei A.
Afiliación
  • Dickerman BA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
  • Torfadottir JE; Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland.
  • Valdimarsdottir UA; Icelandic Cancer Registry, Reykjavik, Iceland.
  • Giovannucci E; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
  • Wilson KM; Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland.
  • Aspelund T; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
  • Tryggvadottir L; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
  • Sigurdardottir LG; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  • Harris TB; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
  • Launer LJ; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
  • Gudnason V; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  • Markt SC; Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland.
  • Mucci LA; Icelandic Heart Association, Kopavogur, Iceland.
Cancer ; 125(16): 2877-2885, 2019 08 15.
Article en En | MEDLINE | ID: mdl-31179538
BACKGROUND: The World Cancer Research Fund classifies as "strong evidence" the link between obesity and the risk of advanced prostate cancer. In light of the different hormonal profiles associated with where adipose is stored, this study investigated the role of objectively measured body fat distribution and the risk of clinically relevant prostate cancer. METHODS: This was a prospective study of 1832 men in the Age, Gene/Environment Susceptibility-Reykjavik study. From 2002 to 2006, participants underwent baseline computed tomography imaging of fat deposition, bioelectric impedance analysis, and measurement of body mass index (BMI) and waist circumference. Men were followed through linkage with nationwide cancer registries for the incidence of total (n = 172), high-grade (Gleason grade ≥8; n = 43), advanced (≥cT3b/N1/M1 at diagnosis or fatal prostate cancer over follow-up; n = 41), and fatal prostate cancer (n = 31) through 2015. Cox regression was used to evaluate the association between adiposity measures and prostate cancer outcomes. RESULTS: Among all men, visceral fat (hazard ratio [HR], 1.31 per 1-standard deviation [SD] increase; 95% confidence interval [CI], 1.00-1.72) and thigh subcutaneous fat (HR, 1.37 per 1-SD increase; 95% CI, 1.00-1.88) were associated with risk of advanced and fatal disease, respectively. Among men who were leaner based on BMI, visceral fat was associated with both advanced and fatal disease. BMI and waist circumference were associated with a higher risk of advanced and fatal disease. No adiposity measures were associated with total or high-grade disease. CONCLUSIONS: Specific fat depots as well as BMI and waist circumference were associated with the risk of aggressive prostate cancer, which may help to elucidate underlying mechanisms and target intervention strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Distribución de la Grasa Corporal Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Cancer Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Distribución de la Grasa Corporal Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Cancer Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos