Design and development of 1,3,4-oxadiazole derivatives as potential inhibitors of acetylcholinesterase to ameliorate scopolamine-induced cognitive dysfunctions.

Mishra, Puja; Sharma, Piyoosh; Tripathi, Prabhash Nath; Gupta, Sukesh Kumar; Srivastava, Pavan; Seth, Ankit; Tripathi, Avanish; Krishnamurthy, Sairam; Shrivastava, Sushant Kumar

Mishra, Puja; Sharma, Piyoosh; Tripathi, Prabhash Nath; Gupta, Sukesh Kumar; Srivastava, Pavan; Seth, Ankit; Tripathi, Avanish; Krishnamurthy, Sairam; Shrivastava, Sushant Kumar.

Afiliación

Mishra P; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India.
Sharma P; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India.
Tripathi PN; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India.
Gupta SK; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India.
Srivastava P; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India.
Seth A; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India.
Tripathi A; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India.
Krishnamurthy S; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India.
Shrivastava SK; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India. Electronic address: skshrivastava.phe@itbhu.ac.in.

Bioorg Chem ; 89: 103025, 2019 08.

Article en En | MEDLINE | ID: mdl-31176239

Asunto(s)

Acetilcolinesterasa/metabolismo; Inhibidores de la Colinesterasa/farmacología; Disfunción Cognitiva/tratamiento farmacológico; Desarrollo de Medicamentos; Oxadiazoles/farmacología; Péptidos beta-Amiloides/antagonistas & inhibidores; Péptidos beta-Amiloides/metabolismo; Animales; Reacción de Prevención/efectos de los fármacos; Butirilcolinesterasa/metabolismo; Inhibidores de la Colinesterasa/administración & dosificación; Inhibidores de la Colinesterasa/síntesis química; Disfunción Cognitiva/inducido químicamente; Relación Dosis-Respuesta a Droga; Electrophorus; Caballos; Humanos; Masculino; Memoria/efectos de los fármacos; Ratones; Estructura Molecular; Oxadiazoles/administración & dosificación; Oxadiazoles/síntesis química; Fragmentos de Péptidos/antagonistas & inhibidores; Fragmentos de Péptidos/metabolismo; Agregado de Proteínas/efectos de los fármacos; Escopolamina/administración & dosificación; Relación Estructura-Actividad

Palabras clave

1,3,4-Oxadiazole; 4-Aminopyridine; Acetylcholinesterase; Butyrylcholinesterase; Molecular hybridization

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxadiazoles / Acetilcolinesterasa / Inhibidores de la Colinesterasa / Disfunción Cognitiva / Desarrollo de Medicamentos Límite: Animals / Humans / Male Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos

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