Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-&#945;-synuclein-A53T mouse model, correlating with increased nitration and aggregation of &#945;-synuclein and exacerbation of motor impairment.

Maki, Richard A; Holzer, Michael; Motamedchaboki, Khatereh; Malle, Ernst; Masliah, Eliezer; Marsche, Gunther; Reynolds, Wanda F

Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-α-synuclein-A53T mouse model, correlating with increased nitration and aggregation of α-synuclein and exacerbation of motor impairment.

Maki, Richard A; Holzer, Michael; Motamedchaboki, Khatereh; Malle, Ernst; Masliah, Eliezer; Marsche, Gunther; Reynolds, Wanda F.

Afiliación

Maki RA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Holzer M; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria.
Motamedchaboki K; Tumor Initiation & Maintenance Program and NCI Cancer Centre Proteomics Facility, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Malle E; Gottfried Schatz Research Center, Division of Molecular Biology and Biochemistry, Medical University of Graz, Austria.
Masliah E; Molecular Neuropathology Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA; Department Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA; Department of Pathology, School of Medicin
Marsche G; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria.
Reynolds WF; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. Electronic address: wreynolds@sbpdiscovery.org.

Free Radic Biol Med ; 141: 115-140, 2019 09.

Article en En | MEDLINE | ID: mdl-31175983

Asunto(s)

Modelos Animales de Enfermedad; Trastornos Motores/enzimología; Neuronas/enzimología; Enfermedad de Parkinson/enzimología; Peroxidasa/metabolismo; Sustancia Negra/enzimología; Animales; Carbono/química; Epítopos/química; Femenino; Humanos; Masculino; Aprendizaje por Laberinto; Ratones; Ratones Transgénicos; Trastornos Motores/fisiopatología; Destreza Motora; Nitrógeno/química; Estrés Oxidativo; Enfermedad de Parkinson/fisiopatología; Peroxidasa/genética; Sustancia Negra/citología

Palabras clave

Alpha synuclein; Carbamylation; Dementia with lewy bodies; ER stress; Hippocampus CA2 region; Hypochlorous acid; MPO-H(2)O(2)-chloride system; Myeloperoxidase; Nitration; Parkinson's disease; Reactive oxygen species; Synucleinopathies; Unfolded protein response

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Sustancia Negra / Peroxidasa / Modelos Animales de Enfermedad / Trastornos Motores / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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