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Human papillomavirus genotypes in cervical and other HPV-related anogenital cancer in Rwanda, according to HIV status.
Mpunga, Tharcisse; Chantal Umulisa, Marie; Tenet, Vanessa; Rugwizangoga, Belson; Milner, Danny A; Munyanshongore, Cyprien; Heideman, Daniëlle A M; Bleeker, Maaike C G; Tommasino, Massimo; Franceschi, Silvia; Baussano, Iacopo; Gheit, Tarik; Sayinzoga, Felix; Clifford, Gary M.
Afiliación
  • Mpunga T; Butaro Cancer Centre of Excellence, Ministry of Health, Butaro, Rwanda.
  • Chantal Umulisa M; Rwanda Biomedical Centre, Ministry of Health of Rwanda, Kigali, Rwanda.
  • Tenet V; International Agency for Research on Cancer, Lyon, France.
  • Rugwizangoga B; International Agency for Research on Cancer, Lyon, France.
  • Milner DA; Department of Pathology, University Teaching Hospital of Kigali, Kigali, Rwanda.
  • Munyanshongore C; University of Rwanda School of Medicine and Pharmacy, Kigali, Rwanda.
  • Heideman DAM; American Society for Clinical Pathology, Chicago, IL.
  • Bleeker MCG; University of Rwanda, School of Public Health, Kigali, Rwanda.
  • Tommasino M; Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, Amsterdam, The Netherlands.
  • Franceschi S; Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, Amsterdam, The Netherlands.
  • Baussano I; International Agency for Research on Cancer, Lyon, France.
  • Gheit T; Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
  • Sayinzoga F; International Agency for Research on Cancer, Lyon, France.
  • Clifford GM; International Agency for Research on Cancer, Lyon, France.
Int J Cancer ; 146(6): 1514-1522, 2020 03 15.
Article en En | MEDLINE | ID: mdl-31173641
The study aim was to describe human papillomavirus (HPV)-attributable cancer burden in Rwanda, according to anogenital cancer site, HPV type, age and HIV status. Tissue specimens of cervical, vulvar, vaginal, penile and anal cancer diagnosed in 2012-2018 were retrieved from three cancer referral hospitals and tested for high-risk (HR) HPV DNA. Cervical cancer represented the majority of cases (598 of 738), of which 96.0% were HR-HPV positive. HPV-attributable fractions in other cancer sites varied from 53.1% in 81 penile, through 76.7% in 30 vulvar, 83.3% in 24 vaginal, up to 100% in 5 anal cases. HPV16 was the predominant HR-HPV type in cervical cancer (55.0%), followed by HPV18 (16.6%) and HPV45 (13.4%). HPV16 also predominated in other cancer sites (60-80% of HR-HPV-attributable fraction). For cervical cancer, type-specific prevalence varied significantly by histology (higher alpha-9 type prevalence in 509 squamous cell carcinoma vs. higher alpha-7 type prevalence in 80 adenocarcinoma), but not between 501 HIV-negative and 97 HIV-positive cases. With respect to types targeted, and/or cross-protected, by HPV vaccines, HPV16/18 accounted for 73%, HPV31/33/45/52/58 for an additional 22% and other HR-HPV types for 5%, of HPV-attributable cancer burden, with no significant difference by HIV status nor age. These data highlight the preventive potential of the ongoing national HPV vaccination program in Rwanda, and in sub-Saharan Africa as a whole. Importantly for this region, the impact of HIV on the distribution of causal HPV types was relatively minor, confirming type-specific relevance of HPV vaccines, irrespective of HIV status.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Ano / Papillomaviridae / Neoplasias del Pene / Infecciones por VIH / Infecciones por Papillomavirus / Neoplasias de los Genitales Femeninos Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: Int J Cancer Año: 2020 Tipo del documento: Article País de afiliación: Ruanda Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Ano / Papillomaviridae / Neoplasias del Pene / Infecciones por VIH / Infecciones por Papillomavirus / Neoplasias de los Genitales Femeninos Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: Int J Cancer Año: 2020 Tipo del documento: Article País de afiliación: Ruanda Pais de publicación: Estados Unidos