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Prenatal bisphenol a and phthalate exposure are risk factors for male reproductive system development and cord blood sex hormone levels.
Sunman, Birce; Yurdakök, Kadriye; Kocer-Gumusel, Belma; Özyüncü, Özgür; Akbiyik, Filiz; Balci, Aylin; Özkemahli, Gizem; Erkekoglu, Pinar; Yurdakök, Murat.
Afiliación
  • Sunman B; Department of Pediatrics, Gülhane Education and Research Hospital, Ankara, Turkey. Electronic address: brchmz@gmail.com.
  • Yurdakök K; Department of Pediatrics, Social Pediatrics Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Kocer-Gumusel B; Department of Toxicology, Hacettepe University Faculty of Pharmacy, Ankara, Turkey; Department of Toxicology, Lokman Hekim University Faculty of Pharmacy, Ankara, Turkey.
  • Özyüncü Ö; Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Akbiyik F; Department of Medical Biochemistry, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Balci A; Department of Toxicology, Hacettepe University Faculty of Pharmacy, Ankara, Turkey.
  • Özkemahli G; Department of Toxicology, Hacettepe University Faculty of Pharmacy, Ankara, Turkey; Department of Toxicology, Binali Yildirim University Faculty of Pharmacy, Erzincan, Turkey.
  • Erkekoglu P; Department of Toxicology, Hacettepe University Faculty of Pharmacy, Ankara, Turkey.
  • Yurdakök M; Department of Pediatrics, Neonatology Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Reprod Toxicol ; 87: 146-155, 2019 08.
Article en En | MEDLINE | ID: mdl-31170452
Bisphenol A (BPA) and phthalates can adversely affect the fetal development. However, observational studies on the effects of these chemicals on fetal male reproductive system are still limited. A hundred of umbilical cord blood samples were analyzed for the levels of BPA, di-2-ethylhexyl phthalate (DEHP), mono-2-ethylhexyl phthalate (MEHP), and sex hormones. After birth, male newborns underwent physical examination that included measurements of anogenital distance, stretched penile length (SPL), and penile width. BPA, DEHP and MEHP levels were detectable in ≈99% of cord blood samples. In covariate-adjusted models, cord blood BPA levels were inversely associated with SPL of newborns and positively associated with cord blood estradiol levels. In addition, there was a significant inverse relationship between cord blood DEHP levels and anogenital distance index of newborn males. Our results suggest that in utero BPA and DEHP exposure exerted adverse effects on fetal male reproductive development and cord blood estradiol levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Compuestos de Bencidrilo / Dietilhexil Ftalato / Contaminantes Ambientales / Disruptores Endocrinos / Sangre Fetal / Genitales Masculinos Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Pregnancy Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Compuestos de Bencidrilo / Dietilhexil Ftalato / Contaminantes Ambientales / Disruptores Endocrinos / Sangre Fetal / Genitales Masculinos Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Pregnancy Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos