Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.

Robbins, D S; Shirazi, Y; Drysdale, B E; Lieberman, A; Shin, H S; Shin, M L

Robbins, D S; Shirazi, Y; Drysdale, B E; Lieberman, A; Shin, H S; Shin, M L.

Afiliación

Robbins DS; Department of Pathology, University of Maryland School of Medicine, Baltimore 21201.

J Immunol ; 139(8): 2593-7, 1987 Oct 15.

Article en En | MEDLINE | ID: mdl-3116087

RESUMEN

Stimulation of rat astrocytes in vitro by calcium ionophore A23187 and/or lipopolysaccharide results in the generation of a cytotoxic factor that is functionally similar to the previously described macrophage-derived cytotoxic factor, tumor necrosis factor. Like the macrophage product, the astrocyte cytotoxic factor kills murine L 929 cell targets. In addition, it kills rat oligodendrocytes, the myelin-producing cells of the central nervous system. Human recombinant tumor necrosis factor also has cytotoxic activity directed against rat oligodendrocytes.

Asunto(s)

Astrocitos/fisiología; Citotoxinas/fisiología; Enfermedades Desmielinizantes/fisiopatología; Neuroglía/fisiología; Oligodendroglía/fisiología; Animales; Calcimicina/farmacología; Inflamación/fisiopatología; Lipopolisacáridos/farmacología; Conejos; Ratas; Proteínas Recombinantes/farmacología; Factor de Necrosis Tumoral alfa/inmunología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligodendroglía / Neuroglía / Astrocitos / Enfermedades Desmielinizantes / Citotoxinas Límite: Animals Idioma: En Revista: J Immunol Año: 1987 Tipo del documento: Article Pais de publicación: Estados Unidos

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