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Cholesterol removal from human plasma with biologically modified cryogels.
Uzunoglu, Gizem; Çimen, Duygu; Bereli, Nilay; Çetin, Kemal; Denizli, Adil.
Afiliación
  • Uzunoglu G; a Biochemistry Division, Department of Chemistry , Hacettepe University , Ankara , Turkey.
  • Çimen D; a Biochemistry Division, Department of Chemistry , Hacettepe University , Ankara , Turkey.
  • Bereli N; a Biochemistry Division, Department of Chemistry , Hacettepe University , Ankara , Turkey.
  • Çetin K; b Biochemistry Division, Department of Chemistry, Faculty of Science , Necmettin Erbakan University , Konya , Turkey.
  • Denizli A; a Biochemistry Division, Department of Chemistry , Hacettepe University , Ankara , Turkey.
J Biomater Sci Polym Ed ; 30(14): 1276-1290, 2019 10.
Article en En | MEDLINE | ID: mdl-31156065
In this study, low molecular weight heparin immobilized P(HEMA) cryogels were fabricated for the removal of LDL-C in hypercholesterolemic human plasma. After characterization studies for P(HEMA) cryogels, effects of the parameters including medium pH, CNBr concentration, heparin concentration and contact time on heparin immobilization were investigated. Blood compatibility and cell adhesion tests were also performed, and platelet and leucocyte loss for P(HEMA)-Hp cryogels were found to be 2.95% and 4.91%, respectively. Maximum adsorption capacity for LDL-C from hypercholesterolemic human plasma was found to be 26.7 mg/g for P(HEMA)-Hp cryogel while it was only 1.67 mg/g for bare P(HEMA) cryogel. The P(HEMA)-Hp cryogels exhibit high desorption ratios up to 96% after 10 adsorption-desorption cycles with no significant decrease in the adsorption capacity. The findings indicated that these reusable P(HEMA)-based cryogels proposed good alternative adsorbents for removal of LDL-C.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Criogeles / Fraccionamiento Químico / LDL-Colesterol Límite: Humans Idioma: En Revista: J Biomater Sci Polym Ed Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2019 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Criogeles / Fraccionamiento Químico / LDL-Colesterol Límite: Humans Idioma: En Revista: J Biomater Sci Polym Ed Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2019 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido