Your browser doesn't support javascript.
loading
Decreased maternal serum cortistatin levels in pregnancies with gestational diabetes mellitus.
Akbas, Murat; Koltan, Semra Oruc; Koyuncu, Faik Mumtaz; Artunc Ulkumen, Burcu; Taneli, Fatma; Ozdemir, Habib.
Afiliación
  • Akbas M; Department of Obstetrics and Gynecology, Perinatology Division, Manisa Celal Bayar University, Manisa, Turkey.
  • Koltan SO; Department of Obstetrics and Gynecology, Manisa Celal Bayar University, Manisa, Turkey.
  • Koyuncu FM; Department of Obstetrics and Gynecology, Perinatology Division, Manisa Celal Bayar University, Manisa, Turkey.
  • Artunc Ulkumen B; Department of Obstetrics and Gynecology, Perinatology Division, Manisa Celal Bayar University, Manisa, Turkey.
  • Taneli F; Department of Medical Biochemistry, Manisa Celal Bayar University, Manisa, Turkey.
  • Ozdemir H; Department of Medical Biochemistry, Manisa Celal Bayar University, Manisa, Turkey.
J Matern Fetal Neonatal Med ; 33(7): 1239-1244, 2020 Apr.
Article en En | MEDLINE | ID: mdl-31154879
Objective: To investigate serum cortistatin levels in women with gestational diabetes mellitus (GDM) and women with uncomplicated pregnancies.Material and methods: This case-control study consisted of 40 pregnancies with GDM and 41 healthy singleton pregnancies matched for maternal and gestational age. The maternal serum levels of cortistatin were measured with enzyme-linked immunosorbent assay and compared between groups.Results: Cortistatin levels were significantly lower in GDM group (48.85 ± 20.18 versus 65.84 ± 33.98 ng/ml, p = .008). There was a statistically significant difference in cortistatin levels between different treatment modalities and control group (χ2(2) = 8.828, p = .012). Pairwise comparisons showed that diet group had significantly lower CST levels than control group (p = .012). Serum cortistatin levels were negatively correlated with serum insulin and glucose levels and HOMA-IR (r = -0.358, p = .001; r = -0.303, p = .006; r = -0.444, p < .001, respectively).Conclusion: Cortistatin levels were significantly lower in GDM pregnancies and related to serum insulin and glucose levels and HOMA-IR in pregnancy. This may help to better clarify the mechanism of GDM pathogenesis.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neuropéptidos / Diabetes Gestacional Tipo de estudio: Observational_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Matern Fetal Neonatal Med Asunto de la revista: OBSTETRICIA / PERINATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neuropéptidos / Diabetes Gestacional Tipo de estudio: Observational_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Matern Fetal Neonatal Med Asunto de la revista: OBSTETRICIA / PERINATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido