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Helminth Therapy - From the Parasite Perspective.
Sobotková, Katerina; Parker, William; Levá, Jana; Ruzková, Jirina; Lukes, Julius; Jirku Pomajbíková, Katerina.
Afiliación
  • Sobotková K; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, 370 05 Ceské Budejovice, Czech Republic.
  • Parker W; Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
  • Levá J; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, 370 05 Ceské Budejovice, Czech Republic; Faculty of Science, University of South Bohemia, 370 05 Ceské Budejovice, Czech Republic.
  • Ruzková J; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, 370 05 Ceské Budejovice, Czech Republic.
  • Lukes J; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, 370 05 Ceské Budejovice, Czech Republic; Faculty of Science, University of South Bohemia, 370 05 Ceské Budejovice, Czech Republic.
  • Jirku Pomajbíková K; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, 370 05 Ceské Budejovice, Czech Republic; Faculty of Science, University of South Bohemia, 370 05 Ceské Budejovice, Czech Republic. Electronic address: pomajbikova@paru.cas.cz.
Trends Parasitol ; 35(7): 501-515, 2019 07.
Article en En | MEDLINE | ID: mdl-31153721
Studies in animal models and humans suggest that intentional exposure to helminths or helminth-derived products may hold promise for treating chronic inflammatory-associated diseases (CIADs). Although the mechanisms underlying 'helminth therapy' are being evaluated, little attention has been paid to the actual organisms in use. Here we examine the notion that, because of the complexity of biological symbiosis, intact helminths rather than helminth-derived products are likely to prove more useful for clinical purposes. Further, weighing potential cost/benefit ratios of various helminths along with other factors, such as feasibility of production, we argue that the four helminths currently in use for CIAD treatments in humans were selected more by happenstance than by design, and that other candidates not yet tested may prove superior.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helmintos / Inflamación Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Trends Parasitol Asunto de la revista: PARASITOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helmintos / Inflamación Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Trends Parasitol Asunto de la revista: PARASITOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Reino Unido