METTL3 mediated m<sup>6</sup>A modification plays an oncogenic role in cutaneous squamous cell carcinoma by regulating &#916;Np63.

Zhou, Renpeng; Gao, Ya; Lv, Dongze; Wang, Chen; Wang, Danru; Li, Qingfeng

METTL3 mediated m⁶A modification plays an oncogenic role in cutaneous squamous cell carcinoma by regulating ΔNp63.

Zhou, Renpeng; Gao, Ya; Lv, Dongze; Wang, Chen; Wang, Danru; Li, Qingfeng.

Afiliación

Zhou R; Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai, 200011, PR China.
Gao Y; Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai, 200011, PR China.
Lv D; Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai, 200011, PR China.
Wang C; Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai, 200011, PR China.
Wang D; Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai, 200011, PR China. Electronic address: wangdanru1776@163.com.
Li Q; Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai, 200011, PR China. Electronic address: dr.liqingfeng@shsmu.edu.cn.

Biochem Biophys Res Commun ; 515(2): 310-317, 2019 07 23.

Article en En | MEDLINE | ID: mdl-31153635

Asunto(s)

Carcinoma de Células Escamosas/metabolismo; Metiltransferasas/metabolismo; Neoplasias Cutáneas/metabolismo; Factores de Transcripción/metabolismo; Proteínas Supresoras de Tumor/metabolismo; Adenosina/análogos & derivados; Adenosina/metabolismo; Animales; Carcinogénesis/genética; Carcinogénesis/metabolismo; Carcinogénesis/patología; Carcinoma de Células Escamosas/genética; Carcinoma de Células Escamosas/patología; Diferenciación Celular/genética; Diferenciación Celular/fisiología; Línea Celular Tumoral; Autorrenovación de las Células/genética; Autorrenovación de las Células/fisiología; Regulación Neoplásica de la Expresión Génica; Técnicas de Silenciamiento del Gen; Xenoinjertos; Humanos; Metiltransferasas/antagonistas & inhibidores; Metiltransferasas/genética; Ratones; Ratones Desnudos; Procesamiento Postranscripcional del ARN; ARN Mensajero/genética; ARN Mensajero/metabolismo; Neoplasias Cutáneas/genética; Neoplasias Cutáneas/patología; Factores de Transcripción/genética; Proteínas Supresoras de Tumor/genética

Palabras clave

Cutaneous squamous cell carcinoma; METTL3; m(6)A modification; ΔNp63

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Factores de Transcripción / Carcinoma de Células Escamosas / Proteínas Supresoras de Tumor / Metiltransferasas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos

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