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Intra- and inter-observer variability in dependence of T1-time correction for common dynamic contrast enhanced MRI parameters in prostate cancer patients.
Daniel, Michaela; Polanec, Stephan H; Wengert, Georg; Clauser, Paola; Pinker, Katja; Helbich, Thomas H; Georg, Dietmar; Baltzer, Pascal A T.
Afiliación
  • Daniel M; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Austria; Department of Radiotherapy, Medical University of Vienna/AKH Vienna, Austria.
  • Polanec SH; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Austria; Department of Biomedical Imaging and Image-Guided Therapy, Medical University and General Hospital of Vienna, Austria.
  • Wengert G; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Austria; Department of Biomedical Imaging and Image-Guided Therapy, Medical University and General Hospital of Vienna, Austria.
  • Clauser P; Department of Biomedical Imaging and Image-Guided Therapy, Medical University and General Hospital of Vienna, Austria.
  • Pinker K; Department of Biomedical Imaging and Image-Guided Therapy, Medical University and General Hospital of Vienna, Austria.
  • Helbich TH; Department of Biomedical Imaging and Image-Guided Therapy, Medical University and General Hospital of Vienna, Austria.
  • Georg D; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Austria; Department of Radiotherapy, Medical University of Vienna/AKH Vienna, Austria.
  • Baltzer PAT; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Austria; Department of Biomedical Imaging and Image-Guided Therapy, Medical University and General Hospital of Vienna, Austria. Electronic address: pascal.baltzer@meduniwien.ac.at.
Eur J Radiol ; 116: 27-33, 2019 Jul.
Article en En | MEDLINE | ID: mdl-31153570
BACKGROUND: Dynamic contrast enhanced (DCE) MRI parameters are potential biomarkers to characterise tumour vasculature and distinguish it from the non-cancerous blood vessel system within the prostate. However, the inevitable presence of intra- and inter-observer variabilities is challenging in this context. Additionally, pre-contrast T1-time correction is a prerequisite to gain quantitative DCE parameters in the first place. The current study investigated the effect of individualized T1-time correction on intra- and inter-reader variability for quantitative DCE-parameters in prostatic lesions. METHODS: In this IRB-approved retrospective study, two experienced radiologists assessed DCE parameters using individually measured (A) and fixed (B) T1-times twice with a time difference of three weeks. The dataset consisted of 35 MRI-guided biopsy-proven prostate cancer lesions. Limits of agreement (LoA) and coefficients of variability (CoV) were calculated to assess intra- and inter-reader variabilities of the parameters. RESULTS: With exception of kep, for all DCE parameters both intra- and inter-reader CoV were smaller in B compared to A. Absolute kep values were largely insensitive to T1-time correction induced bias. The mean intra-reader CoVs [5%, 95% percentile] (over all four DCE parameters and both readers) were 6.7% [0.5%, 15.1%] in A and 3.9% [0.2%, 11.0%] in B. The inter-reader CoVs were 9.0% [0.6%, 25.8%] (A) and 7.0% [0.3%, 25.4%] (B). CONCLUSIONS: T1-time correction has a significant influence on the intra- and inter-reader variability. By applying individually measured T1-time correction, both intra- and inter-observer variability were found to increase. Out of all investigated DCE parameters, kep is the most robust to this investigated bias.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Imagen por Resonancia Magnética / Aumento de la Imagen / Medios de Contraste Tipo de estudio: Observational_studies Límite: Aged / Humans / Male Idioma: En Revista: Eur J Radiol Año: 2019 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Imagen por Resonancia Magnética / Aumento de la Imagen / Medios de Contraste Tipo de estudio: Observational_studies Límite: Aged / Humans / Male Idioma: En Revista: Eur J Radiol Año: 2019 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Irlanda