Your browser doesn't support javascript.
loading
Overexpression of IGFBP2 mRNA predicts poor survival in patients with glioblastoma.
Yuan, Qing; Cai, Hong-Qing; Zhong, Yi; Zhang, Min-Jie; Cheng, Zhi-Jian; Hao, Jia-Jie; Wang, Ming-Rong; Wan, Jing-Hai.
Afiliación
  • Yuan Q; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, P.R. China.
  • Cai HQ; State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China.
  • Zhong Y; Department of Neurosurgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China wanjinghai@sina.com phonecy@126.com.
  • Zhang MJ; State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China.
  • Cheng ZJ; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, P.R. China.
  • Hao JJ; State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China.
  • Wang MR; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, P.R. China.
  • Wan JH; State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China.
Biosci Rep ; 39(6)2019 06 28.
Article en En | MEDLINE | ID: mdl-31138764
The prognosis of patients with glioblastoma (GBM) is dismal. It has been reported that Insulin-like growth factor (IGF) binding protein 2 (IGFBP2) is associated with the mobility and invasion of tumor cells. We investigated the expression of IGFBP2 mRNA in GBMs and its clinical relevance, using tissue microarrays and RNAscope in situ hybridization in 180 GBMs and 13 normal or edematous tissues. The correlations between the expression and clinical pathological parameters as well as some other biomarkers were analyzed. Overexpression of IGFBP2 mRNA was observed in 23.9% of tumors tested. No expression of IGFBP2 mRNA was detected in normal or edematous tissues. Kaplan-Meier survival analysis showed that the survival time of all the patients with high IGFBP2 tumors had shorter survival than those with low IGFBP2 (P<0.01). Univariate regression and multivariate regression both indicated that the expression of IGFBP2 transcript level was an independent prognostic factor (P=0.008 and 0.007, respectively). Furthermore, expression of IGFBP2 mRNA was related to the occurrence of isocitrate dehydrogenase 1 (IDH1) mutation, high heat shock protein 27 (Hsp27) expression and telomerase reverse transcriptase (TERT) promoter mutation (TERTp+) (P=0.013, 0.015 and 0.016, respectively), and patients with TERTp+/IGFBP2high showed the shortest survival. In conclusion, IGFBP2 mRNA expression status is an independent prognostic biomarker in GBMs, and the combination of IGFBP2 mRNA and TERTp status might serve as a prognostic indicator in patients with GBM.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / ARN Neoplásico / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / Glioblastoma / Proteína 2 de Unión a Factor de Crecimiento Similar a la Insulina / Proteínas de Neoplasias Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Biosci Rep Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / ARN Neoplásico / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / Glioblastoma / Proteína 2 de Unión a Factor de Crecimiento Similar a la Insulina / Proteínas de Neoplasias Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Biosci Rep Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido