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[Adiponectin ameliorated pancreatic islet mitochondrial injury induced by chronic intermittent hypoxia].
Ding, W X; Zhang, Q; Ge, L Y; Dong, Y B; Ding, N; Zhang, X L.
Afiliación
  • Ding WX; Department of Respirology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
  • Zhang Q; Department of Respirology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
  • Ge LY; Department of Respirology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
  • Dong YB; Department of Respirology and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
  • Ding N; Department of Respirology and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
  • Zhang XL; Department of Respirology and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Zhonghua Yi Xue Za Zhi ; 99(18): 1380-1384, 2019 May 14.
Article en Zh | MEDLINE | ID: mdl-31137124
Objective: To explore the effect of adiponectin (APN) on islet injury induced by chronic intermittent hypoxia (CIH). Methods: Thirty-six SD rats were randomly divided into three groups: Normal control (NC), CIH, and CIH + APN groups. The rats in the CIH and CIH+APN groups received an intermittent hypoxia exposure while the rats in NC group received the room air only. The rats in CIH+APN group received the intravenous injection of APN. The intermittent hypoxia events persisted 8 hours a day and last for 35 days. The fasting blood glucose and fasting insulin were detected at the time of 0, 7, 14, 21, 28, and 35 day. After 35 days, the level of serum adiponectin, and adenosine triphosphate (ATP) level, superoxide dismutase (SOD), malondialdehyde (MDA), the mRNA levels of mitochondrial oxidative phosphorylation function and mitochondrial synthesis gene, and the protein level of mitochondrial and cytoplasmic cytochrome C of pancreatic islet were detected. Results: The glucose and insulin level had no statistically differences among three groups at different time points (all P>0.05). However, compared with NC and CIH+APN groups, CIH reduced the serum adiponectin [(7 265±2 209) ng/ml, (6 536±1 678) ng/ml vs (4 923±1 742) ng/ml, both P<0.05], ATP levels [(30.92±1.12) nmol/mg, (26.55±0.72) nmol/mg vs (20.22±1.47) nmol/mg, both P<0.05], mRNA levels of mitochondria oxidative phosphorylation function and mitochondrial synthesis gene, the activity of SOD, and the rate of mitochondrial/cytoplasmic cytochrome C protein level while increased the MDA level in pancreatic islet. Compared with NC group, the MDA level increased (P<0.05) and the APN level had no statistically difference, while the level of other indicators decreased in CIH+APN group (all P<0.05). Conclusion: APN ameliorates the pancreatic islet injury induced by CIH through inhibition of oxidative stress.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Islotes Pancreáticos Límite: Animals Idioma: Zh Revista: Zhonghua Yi Xue Za Zhi Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Islotes Pancreáticos Límite: Animals Idioma: Zh Revista: Zhonghua Yi Xue Za Zhi Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: China