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Curative thoraco-systemic therapy plus local treatment to the brain for extensive disease-small-cell lung cancer with metastasis only to the brain.
Shibata, Kazuhiko; Iwasa, Keiichi; Takanaka, Tsuyoshi; Yachi, Tsuyoshi; Okazaki, Akihito; Shiba, Yasutaka; Kasahara, Kazuo.
Afiliación
  • Shibata K; Division of Medical Oncology, Department of Medicine, Kouseiren Takaoka Hospital 5-10 Eirakumachi, Takaoka, Toyama, Japan.
  • Iwasa K; Division of Medical Oncology, Department of Medicine, Kouseiren Takaoka Hospital 5-10 Eirakumachi, Takaoka, Toyama, Japan.
  • Takanaka T; Department of Radiation Oncology, Kouseiren Takaoka Hospital, 5-10 Eirakumachi, Takaoka, Toyama, Japan.
  • Yachi T; Department of Thoracic and Cardiovascular Surgery, Kouseiren Takaoka Hospital, 5-10 Eirakumachi, Takaoka, Toyama, Japan.
  • Okazaki A; Division of Respiratory Medicine, Department of Medicine, Kouseiren Takaoka Hospital, 5-10 Eirakumachi, Takaoka, Toyama, Japan.
  • Shiba Y; Division of Respiratory Medicine, Department of Medicine, Kouseiren Takaoka Hospital, 5-10 Eirakumachi, Takaoka, Toyama, Japan.
  • Kasahara K; Department of Hematology and Respiratory Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takaramachi, Kanazawa, Ishikawa, Japan.
Jpn J Clin Oncol ; 49(7): 687-690, 2019 Jul 01.
Article en En | MEDLINE | ID: mdl-31135898
We reviewed 11 cases of extensive disease (ED)-SCLC and metastasis only to the brain treated during 2011-14. All patients underwent definitive therapy similar to that for limited disease (LD), combined with local treatment for BM. We compared the survival outcomes of these patients to those of patients with LD (n = 29) or other ED (n = 38) during the same period. Three patients had progression of BM at completion of chemotherapy. Ten patients received whole-brain radiotherapy (4 prophylactic, 6 therapeutic), and remaining one elderly patient underwent stereotactic radiosurgery. Finally, 8 and 3 patients achieved a CR or PR of BM, respectively. Five remained free of progression for 21.1-73.2 months. The progression-free and overall survival outcomes of ED-SCLC with brain only metastases were comparable to those of LD and superior to those of other ED. In conclusion, ED-SCLC with metastasis limited to the brain could be treated with curative intent.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Neoplasias Encefálicas / Carcinoma Pulmonar de Células Pequeñas / Neoplasias Pulmonares Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Jpn J Clin Oncol Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Neoplasias Encefálicas / Carcinoma Pulmonar de Células Pequeñas / Neoplasias Pulmonares Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Jpn J Clin Oncol Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido