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Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.
Xue, Ruidong; Chen, Lu; Zhang, Chong; Fujita, Masashi; Li, Ruoyan; Yan, Shu-Mei; Ong, Choon Kiat; Liao, Xiwen; Gao, Qiang; Sasagawa, Shota; Li, Yanmeng; Wang, Jincheng; Guo, Hua; Huang, Qi-Tao; Zhong, Qian; Tan, Jing; Qi, Lisha; Gong, Wenchen; Hong, Zhixian; Li, Meng; Zhao, Jingmin; Peng, Tao; Lu, Yinying; Lim, Kiat Hon Tony; Boot, Arnoud; Ono, Atushi; Chayama, Kazuaki; Zhang, Zemin; Rozen, Steve George; Teh, Bin Tean; Wang, Xin Wei; Nakagawa, Hidewaki; Zeng, Mu-Sheng; Bai, Fan; Zhang, Ning.
Afiliación
  • Xue R; Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University, Beijing 100871, China.
  • Chen L; Department of Hepatobiliary Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
  • Zhang C; Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University, Beijing 100871, China.
  • Fujita M; Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
  • Li R; Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University, Beijing 100871, China.
  • Yan SM; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  • Ong CK; Lymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore 169610, Singapore.
  • Liao X; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
  • Gao Q; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai 200032, China.
  • Sasagawa S; Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
  • Li Y; Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University, Beijing 100871, China.
  • Wang J; Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University, Beijing 100871, China.
  • Guo H; Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
  • Huang QT; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  • Zhong Q; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  • Tan J; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  • Qi L; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
  • Gong W; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
  • Hong Z; Department of Hepatobiliary Surgery, Beijing 302 Hospital, Beijing 100039, China.
  • Li M; Department of Ultrasonography, Beijing 302 Hospital, Beijing 100039, China.
  • Zhao J; Department of Pathology and Hepatology, Beijing 302 Hospital, Beijing 100039, China.
  • Peng T; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
  • Lu Y; Comprehensive Liver Cancer Center, Beijing 302 Hospital, Beijing 100039, China.
  • Lim KHT; Department of Anatomical Pathology, Singapore General Hospital, Singapore 169608, Singapore.
  • Boot A; Centre for Computational Biology, Duke-NUS Medical School, Singapore 169857, Singapore.
  • Ono A; Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
  • Chayama K; Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
  • Zhang Z; Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University, Beijing 100871, China.
  • Rozen SG; Centre for Computational Biology, Duke-NUS Medical School, Singapore 169857, Singapore.
  • Teh BT; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore 169610, Singapore.
  • Wang XW; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Nakagawa H; Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan. Electronic address: hidewaki@ims.u-tokyo.ac.jp.
  • Zeng MS; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China. Electronic address: zengmsh@mail.sysu.edu.cn.
  • Bai F; Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University, Beijing 100871, China. Electronic address: fbai@pku.edu.cn.
  • Zhang N; Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University, Beijing 100871, China; Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China. Electronic
Cancer Cell ; 35(6): 932-947.e8, 2019 06 10.
Article en En | MEDLINE | ID: mdl-31130341
We performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that combined and mixed type cHCC-ICCs are distinct subtypes with different clinical and molecular features. Integrating laser microdissection, cancer cell fraction analysis, and single nucleus sequencing, we revealed both mono- and multiclonal origins in the separate type cHCC-ICCs, whereas combined and mixed type cHCC-ICCs were all monoclonal origin. Notably, cHCC-ICCs showed significantly higher expression of Nestin, suggesting Nestin may serve as a biomarker for diagnosing cHCC-ICC. Our results provide important biological and clinical insights into cHCC-ICC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Biomarcadores de Tumor / Neoplasias Complejas y Mixtas / Colangiocarcinoma / Carcinoma Hepatocelular / Perfilación de la Expresión Génica / Transcriptoma / Nestina / Neoplasias Hepáticas Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Biomarcadores de Tumor / Neoplasias Complejas y Mixtas / Colangiocarcinoma / Carcinoma Hepatocelular / Perfilación de la Expresión Génica / Transcriptoma / Nestina / Neoplasias Hepáticas Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos