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Null results of oxytocin and vasopressin administration across a range of social cognitive and behavioral paradigms: Evidence from a randomized controlled trial.
Tabak, Benjamin A; Teed, Adam R; Castle, Elizabeth; Dutcher, Janine M; Meyer, Meghan L; Bryan, Ronnie; Irwin, Michael R; Lieberman, Matthew D; Eisenberger, Naomi I.
Afiliación
  • Tabak BA; Department of Psychology, Southern Methodist University, Dallas, TX, United States. Electronic address: btabak@smu.edu.
  • Teed AR; Department of Psychology, Southern Methodist University, Dallas, TX, United States.
  • Castle E; Department of Psychology, University of California, Los Angeles, CA, United States.
  • Dutcher JM; Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, United States.
  • Meyer ML; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, United States.
  • Bryan R; Los Angeles Trade-Tech College, Los Angeles, CA, United States.
  • Irwin MR; Department of Psychology, University of California, Los Angeles, CA, United States; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, United States; Cousins Center for Psychoneuroimmunology, Jane and Terry Semel Institute
  • Lieberman MD; Department of Psychology, University of California, Los Angeles, CA, United States; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, United States.
  • Eisenberger NI; Department of Psychology, University of California, Los Angeles, CA, United States.
Psychoneuroendocrinology ; 107: 124-132, 2019 09.
Article en En | MEDLINE | ID: mdl-31128568
Research examining oxytocin and vasopressin in humans has the potential to elucidate neurobiological mechanisms underlying human sociality that have been previously unknown or not well characterized. A primary goal of this work is to increase our knowledge about neurodevelopmental and psychiatric disorders characterized by impairments in social cognition. However, years of research highlighting wide-ranging effects of, in particular, intranasal oxytocin administration have been tempered as the fields of psychology, neuroscience, and other disciplines have been addressing concerns over the reproducibility and validity of research findings. We present a series of behavioral tasks that were conducted using a randomized, double-blind, placebo controlled, between-subjects design, in which our research group found no main effects of oxytocin and vasopressin on a host of social outcomes. In addition to null hypothesis significance testing, we implemented equivalence testing and Bayesian hypothesis testing to examine the sensitivity of our findings. These analyses indicated that 47-83% of our results (depending on the method of post-hoc analysis) had enough sensitivity to detect the absence of a main effect. Our results add to evidence that intranasal oxytocin may have a more limited direct effect on human social processes than initially assumed and suggest that the direct effects of intranasal vasopressin may be similarly limited. Randomized controlled trial registration: NCT01680718.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxitocina / Vasopresinas / Cognición Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Psychoneuroendocrinology Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxitocina / Vasopresinas / Cognición Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Psychoneuroendocrinology Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido