Your browser doesn't support javascript.
loading
Autonomic dysfunction is frequent and disabling in non-paraneoplastic sensory neuronopathies.
Martinez, Alberto Rolim Muro; Martins, Melina Pazian; de Rezende, Thiago Junqueira Ribeiro; Faber, Ingrid; Del Valle Gonzalez Salazar, Carelis; Takazaki, Karen Antônia Girotto; Nucci, Anamarli; França, Marcondes Cavalcante.
Afiliación
  • Martinez ARM; Neurology Department, Neuromuscular Division, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
  • Martins MP; Neurology Department, Neuromuscular Division, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
  • de Rezende TJR; Neurology Department, Neuromuscular Division, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
  • Faber I; Neurology Department, Neuromuscular Division, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
  • Del Valle Gonzalez Salazar C; Neurology Department, Neuromuscular Division, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
  • Takazaki KAG; Neurology Department, Neuromuscular Division, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
  • Nucci A; Neurology Department, Neuromuscular Division, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
  • França MC; Neurology Department, Neuromuscular Division, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil. Electronic address: mcfrancajr@uol.com.br.
J Neurol Sci ; 402: 111-117, 2019 Jul 15.
Article en En | MEDLINE | ID: mdl-31128458
INTRODUCTION: Sensory neuronopathies (SN) are characterized by asymmetric non-length dependent sensory deficits and sensory ataxia. Autonomic dysfunction in SN was not yet evaluated regarding its frequency, characteristics and relationship to sensory deficits. To address these issues, we performed a comprehensive clinical and neurophysiological evaluation of a large cohort of patients with non-paraneoplastic SN (np-SN). METHODS: We enrolled 50 consecutive patients with npSN and 32 age/sex-matched healthy controls. They were clinically evaluated (SCOPA-Aut scale) and underwent neurophysiological autonomic assessment (quantitative sudomotor axon reflex test, heart rate variability and sympathetic skin response). RESULTS: Mean age of patients was 50.9 ±â€¯10.3 years and there were 18 men. npSN patients had higher SCOPA-Aut scores than controls (26.63 ±â€¯12.72 vs. 12.66 ±â€¯9.11, p < .001). QSART was abnormal in 92% of the patients - sweat volumes in all examined sites were smaller among patients (p < .001). Cardiovascular autonomic neuropathy was more frequent in these patients as well (p < .001). CONCLUSION: Altogether our results suggest that autonomic dysfunction in distinct domains is frequent in npSN patients. These findings suggest that the clinical picture of npSN is related to a double neuronopathy: sensory and autonomic.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Autónomo / Enfermedades del Sistema Nervioso Autónomo / Enfermedades del Sistema Nervioso Periférico / Frecuencia Cardíaca Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Sci Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Autónomo / Enfermedades del Sistema Nervioso Autónomo / Enfermedades del Sistema Nervioso Periférico / Frecuencia Cardíaca Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Sci Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos