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Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene.
Chisholm, David R; Lamb, Rebecca; Pallett, Tommy; Affleck, Valerie; Holden, Claire; Marrison, Joanne; O'Toole, Peter; Ashton, Peter D; Newling, Katherine; Steffen, Andreas; Nelson, Amanda K; Mahler, Christoph; Valentine, Roy; Blacker, Thomas S; Bain, Angus J; Girkin, John; Marder, Todd B; Whiting, Andrew; Ambler, Carrie A.
Afiliación
  • Chisholm DR; Department of Chemistry , Durham University , Science Laboratories , South Road , Durham DH1 3LE , UK . Email: andy.whiting@durham.ac.uk.
  • Lamb R; Department of Biosciences , Durham University , South Road , Durham, DH1 3LE , UK.
  • Pallett T; Department of Biosciences , Durham University , South Road , Durham, DH1 3LE , UK.
  • Affleck V; Biophysical Sciences Institute , Department of Physics , Durham University , South Road , Durham , DH1 3LE , UK.
  • Holden C; LightOx Limited , Wynyard Park House , Wynyard Avenue, Wynyard , Billingham , TS22 5TB , UK.
  • Marrison J; Department of Chemistry , Durham University , Science Laboratories , South Road , Durham DH1 3LE , UK . Email: andy.whiting@durham.ac.uk.
  • O'Toole P; Department of Biosciences , Durham University , South Road , Durham, DH1 3LE , UK.
  • Ashton PD; Bioscience Technology Facility , Department of Biology , University of York , York , YO10 5DD , UK.
  • Newling K; Bioscience Technology Facility , Department of Biology , University of York , York , YO10 5DD , UK.
  • Steffen A; Bioscience Technology Facility , Department of Biology , University of York , York , YO10 5DD , UK.
  • Nelson AK; Bioscience Technology Facility , Department of Biology , University of York , York , YO10 5DD , UK.
  • Mahler C; Institut für Anorganische Chemie , Julius-Maximilians-Universität Würzburg , Am Hubland , 97074 Würzburg , Germany.
  • Valentine R; Institut für Anorganische Chemie , Julius-Maximilians-Universität Würzburg , Am Hubland , 97074 Würzburg , Germany.
  • Blacker TS; Institut für Anorganische Chemie , Julius-Maximilians-Universität Würzburg , Am Hubland , 97074 Würzburg , Germany.
  • Bain AJ; High Force Research Ltd. , Bowburn North Industrial Estate , Bowburn , Durham , DH6 5PF , UK.
  • Girkin J; Department of Physics & Astronomy , University College London , Gower Street , London , WC1E 6BT , UK.
  • Marder TB; Department of Physics & Astronomy , University College London , Gower Street , London , WC1E 6BT , UK.
  • Whiting A; Biophysical Sciences Institute , Department of Physics , Durham University , South Road , Durham , DH1 3LE , UK.
  • Ambler CA; Institut für Anorganische Chemie , Julius-Maximilians-Universität Würzburg , Am Hubland , 97074 Würzburg , Germany.
Chem Sci ; 10(17): 4673-4683, 2019 May 07.
Article en En | MEDLINE | ID: mdl-31123578
Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by DC324, has been designed possessing a modular, low molecular weight and 'drug-like' structure which is bioavailable and can be photoactivated by UV-A/405 nm or corresponding two-photon absorption of near-IR (800 nm) light, resulting in powerful cytotoxic activity, ostensibly through the production of ROS in a cellular environment. A variety of in vitro cellular assays confirmed ROS formation and in vivo cytotoxic activity was exemplified via irradiation and subsequent targeted destruction of specific areas of a zebrafish embryo.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Sci Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Sci Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido