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A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Oral Administration of a Heat-Treated Lactobacillus paracasei  Supplement in Infants with Atopic Dermatitis Receiving Topical Corticosteroid Therapy.
Yan, Dah-Chin; Hung, Chih-Hsing; Sy, Leticia B; Lue, Ko-Huang; Shih, I-Hsin; Yang, Chin-Yi; Chen, Li-Chen; Sun, Hai-Lun; Lee, Min-Sheng; Chambard, Julie; Tanguy, Jérôme; Hughes-Formella, Betsy; Nutten, Sophie; Blanchard, Carine.
Afiliación
  • Yan DC; Taipei Chang Gung Memorial Hospital, Taipei, Taiwan.
  • Hung CH; Kaohsiung Municipal Hsiao Kang Hospital, Kaohsiung City, Taiwan.
  • Sy LB; Cardinal Tien Hospital, New Taipei City, Taiwan.
  • Lue KH; Chung Shan Medical University Hospital, Taichung City, Taiwan.
  • Shih IH; Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan.
  • Yang CY; Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan.
  • Chen LC; Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan.
  • Sun HL; Chung Shan Medical University Hospital, Taichung City, Taiwan.
  • Lee MS; Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung City, Taiwan.
  • Chambard J; Nestlé Research, Lausanne, Switzerland.
  • Tanguy J; Nestlé Research, Lausanne, Switzerland.
  • Hughes-Formella B; Independent Consultant, Reinbek, Germany.
  • Nutten S; Nestlé Research, Lausanne, Switzerland.
  • Blanchard C; Nestlé Research, Lausanne, Switzerland, carine.blanchard@rdyo.nestle.com.
Skin Pharmacol Physiol ; 32(4): 201-211, 2019.
Article en En | MEDLINE | ID: mdl-31117100
BACKGROUND/AIMS: Atopic dermatitis (AD) is a common disease in infancy, for which topical steroids are the first-line therapy but have side effects. Innovative approaches are needed to reduce the burden of AD and corticosteroid usage in infants. METHODS: The once-daily consumption of heat-treated probiotic Lactobacillus paracasei GM-080 or placebo for 16 weeks as supplementary approach to topical treatment with fluticasone propionate cream was compared in AD infants aged 4-30 months. Outcomes were SCORAD and its subscores, TEWL, Infants' Dermatitis Quality of Life Index (IDQOL), corticoid "sparing effect," CCL17/TARC, and IgE status. RESULTS: SCORAD, objective SCORAD, itching, and IDQOL decreased significantly (p < 0.001) over the treatment period in both treatment groups. Slight decreases (ns) were noted in TEWL in lesional and unaffected skin and CCL17 levels. There were no differences between the treatment groups. Total IgE increased over the treatment period in both groups, with significantly higher increase in the heat-treated probiotic group (p = 0.038). There was no evidence of a corticoid "sparing effect" by the probiotic. CONCLUSIONS: In this design, the probiotic L. paracasei was not beneficial as a complementary approach to topical corticosteroids in infants with AD. However, slight beneficial effects may have been masked by the moderate potency corticoid.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Probióticos / Dermatitis Atópica / Fármacos Dermatológicos / Fluticasona / Lacticaseibacillus paracasei Tipo de estudio: Clinical_trials Aspecto: Patient_preference Límite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Skin Pharmacol Physiol Asunto de la revista: DERMATOLOGIA / FARMACOLOGIA / FISIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Probióticos / Dermatitis Atópica / Fármacos Dermatológicos / Fluticasona / Lacticaseibacillus paracasei Tipo de estudio: Clinical_trials Aspecto: Patient_preference Límite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Skin Pharmacol Physiol Asunto de la revista: DERMATOLOGIA / FARMACOLOGIA / FISIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza