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VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1.
Capurro, Mariana I; Greenfield, Laura K; Prashar, Akriti; Xia, Sunny; Abdullah, Majd; Wong, Harikesh; Zhong, Xi Zoe; Bertaux-Skeirik, Nina; Chakrabarti, Jayati; Siddiqui, Iram; O'Brien, Catherine; Dong, Xianping; Robinson, Lisa; Peek, Richard M; Philpott, Dana J; Zavros, Yana; Helmrath, Michael; Jones, Nicola L.
Afiliación
  • Capurro MI; Department of Paediatrics and Physiology, University of Toronto; Division of Gastroenterology, Hepatology and Nutrition, and Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Greenfield LK; Department of Paediatrics and Physiology, University of Toronto; Division of Gastroenterology, Hepatology and Nutrition, and Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Prashar A; Department of Paediatrics and Physiology, University of Toronto; Division of Gastroenterology, Hepatology and Nutrition, and Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Xia S; Department of Paediatrics and Physiology, University of Toronto; Division of Gastroenterology, Hepatology and Nutrition, and Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Abdullah M; Department of Paediatrics and Physiology, University of Toronto; Division of Gastroenterology, Hepatology and Nutrition, and Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Wong H; Department of Paediatrics, University of Toronto; Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Zhong XZ; Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Bertaux-Skeirik N; Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USA.
  • Chakrabarti J; Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USA.
  • Siddiqui I; Department of Pathology, University of Toronto; The Hospital for Sick Children, Toronto, Ontario, Canada.
  • O'Brien C; University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Dong X; Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Robinson L; Department of Paediatrics, University of Toronto; Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Peek RM; Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Philpott DJ; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
  • Zavros Y; Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USA.
  • Helmrath M; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Jones NL; Department of Paediatrics and Physiology, University of Toronto; Division of Gastroenterology, Hepatology and Nutrition, and Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. nicola.jones@sickkids.ca.
Nat Microbiol ; 4(8): 1411-1423, 2019 08.
Article en En | MEDLINE | ID: mdl-31110360
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Calcio / Helicobacter pylori / Infecciones por Helicobacter / Canales de Potencial de Receptor Transitorio / Lisosomas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Microbiol Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Calcio / Helicobacter pylori / Infecciones por Helicobacter / Canales de Potencial de Receptor Transitorio / Lisosomas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Microbiol Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido