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Can non-collagenous proteins be employed for the differential diagnosis among fibrous dysplasia, cemento-osseous dysplasia and cemento-ossifying fibroma?
Veltrini, Vanessa Cristina; Figueira, Jéssica Araújo; Santin, Gabriela Cristina; de Sousa, Suzana Cantanhede Orsini Machado; de Araújo, Ney Soares.
Afiliación
  • Veltrini VC; Oral Pathology Discipline, Dentistry Department, State University of Maringa, Av. Mandacaru, 1550, CEP 87080-000, Maringa, PR, Brazil.
  • Figueira JA; Oral Oncology Center, São Paulo State University (UNESP), School of Dentistry, Rua José Bonifácio, 1193, CEP 16015-050, Araçatuba, SP, Brazil. Electronic address: jessica.a.figueira@gmail.com.
  • Santin GC; Pediatric Dentistry Discipline, Dentistry Department, State University of Maringa, Av. Mandacaru, 1550, CEP 87080-000, Maringa, PR, Brazil.
  • de Sousa SCOM; Oral Pathology Department, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, CEP 05508-000, São Paulo, SP, Brazil.
  • de Araújo NS; Oral Pathology Department, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, CEP 05508-000, São Paulo, SP, Brazil.
Pathol Res Pract ; 215(7): 152450, 2019 Jul.
Article en En | MEDLINE | ID: mdl-31109869
Differential diagnosis among fibrous dysplasias, cemento-ossifying fibromas and cemento-osseous dysplasias is difficult, since there is considerable overlap of histologic features, but also extremely important, since they differ greatly in etiology, clinical behaviour, prognosis and terapeuthic approach. There is no data about the use of immunohistochemistry, a viable and accessible technique, for this purpose. The objective of this study was to investigate, comparatively, the immunohistochemical expression of major non-collagenous proteins (osteonectin [ON], osteopontin [OP], bone sialoprotein [BSP] and osteocalcin [OC]) of mineralized tissue extracellular matrix in 22 cases of fibrous dysplasias, 16 of cemento-ossifying fibromas and 16 of cemento-osseous dysplasias. ON maintained the same expression profile in all cases; the staining for OP was negative in fusiform cells producing cementoid globules and weak, as well as heterogeneous, in high mineralized matrixes; there was negativity for BSP in cementoid globules and in the fusiform cells that produce them, differently from the strong positive expression found in the majority of bone trabeculae and their peripheral cuboidal osteoblasts; and finally, the immuno-reactivity for OC was weak, except in cuboidal osteoblasts and osteocytes. We can conclude that the nature of mineralized structure and the cellular phenotype are much more responsible for variability in immunohistochemical profile than the type of lesion (fibrous dysplasias, cemento-ossifying fibromas and cemento-osseous dysplasias) which makes difficult, at least for a while, the use of these proteins with diagnosis purpose.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cementoma / Osteocalcina / Osteonectina / Fibroma Osificante / Osteopontina / Sialoproteína de Unión a Integrina / Displasia Fibrosa Ósea Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Pathol Res Pract Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cementoma / Osteocalcina / Osteonectina / Fibroma Osificante / Osteopontina / Sialoproteína de Unión a Integrina / Displasia Fibrosa Ósea Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Pathol Res Pract Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania