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Could platelet to leucocytic count ratio (PLR) predict sepsis and clinical outcomes in patients with emphysematous pyelonephritis?
Elbaset, M A; Zahran, Mohamad H; Hashem, Abdelwahab; Ghobrial, Fady K; Elrefaie, Eman; Badawy, Mohamed; Shokeir, Ahmed A; Ibrahim, Mohamed Abdelbaset.
Afiliación
  • Elbaset MA; Urology ICU Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
  • Zahran MH; Urology ICU Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
  • Hashem A; Urology ICU Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
  • Ghobrial FK; Urology ICU Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
  • Elrefaie E; Urology ICU Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
  • Badawy M; Urology - Radiology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
  • Shokeir AA; Urology ICU Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
  • Ibrahim MA; Uro-andrology Clinical Fellow, Urology and Nephrology Center, Mansoura University, Egypt. Electronic address: abdelbaset.m.i@gmail.com.
J Infect Chemother ; 25(10): 791-796, 2019 Oct.
Article en En | MEDLINE | ID: mdl-31103341
OBJECTIVES: To study risk factors for sepsis and mortality evaluating the role of platelet to leucocytic count ratio (PLR) as a marker for urosepsis and clinical outcomes in cases of emphysematous pyelonephritis (EPN). MATERIALS: Patients with EPN were retrospectively reviewed. Patients' age, sex, diabetes mellitus (DM), Body Mass Index (BMI), hydronephrosis, types of EPN, air locules volume, serum creatinine, leucocytic count, and platelet count, PLR, albumin, INR and the line of treatment were analyzed as risk factors of sepsis. Correlation between PLR and other variables was done using Pearson correlation coefficient. Univariate and multivariate analyses for sepsis and mortality were performed. RESULTS: Of fifty four patients, 38 patients had SIRS ≥2 criteria on admission. Twenty patients developed sepsis requiring ICU admission. In univariate analysis, male gender, lower BMI, higher INR, higher WBCs count and lower PLR were associated with sepsis (P = 0.0001, 0.009, 0.04, 0.003 and 0.001, respectively). In multivariate analysis, PLR ≤18.4, male sex and BMI ≤24.2 were independent risk factors. Lower PLR directly correlated with serum albumin (P = 0.01) and inversely correlated with serum creatinine and random blood glucose level and Klebsiella infection (P = 0.001, 0.007 and 0.005, respectively). Also, it was correlated with a higher total score of qSOFA and SOFA (P = 0.02 and 0.04). Lower PLR was independent risk factors for death in EPN patients with (P = 0.003). CONCLUSION: EPN is associated with sepsis development. Lower PLR is an independent simple predictor for sepsis and mortality in patients with EPN.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pielonefritis / Choque Séptico / Enfisema Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Infect Chemother Asunto de la revista: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2019 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pielonefritis / Choque Séptico / Enfisema Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Infect Chemother Asunto de la revista: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2019 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Países Bajos