Your browser doesn't support javascript.
loading
Circulating mesenchymal stem cells in sulfur mustard-exposed patients with long-term pulmonary complications.
Ghazanfari, Tooba; Ghaffarpour, Sara; Kariminia, Amina; Salehi, Eisa; Hashemi, Seyed Mahmoud; Ardestani, Sussan Kaboudanian; Gohari Moghadam, Keivan; Mirsharif, Ensieh Sadat; Dilmaghanian, Razieh; Fadaei, Abbas; Faghihzadeh, Soghrat.
Afiliación
  • Ghazanfari T; Immunoregulation Research Center, Shahed University, Tehran, Islamic Republic of Iran; Department of Immunology, Shahed University, 1471, North Karegar Street, Tehran, Islamic Republic of Iran. Electronic address: tghazanfari@yahoo.com.
  • Ghaffarpour S; Immunoregulation Research Center, Shahed University, Tehran, Islamic Republic of Iran.
  • Kariminia A; British Columbia Children's Hospital Research Institute, Pediatrics Department, Faculty of, Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Salehi E; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
  • Hashemi SM; Department of Immunology, School of Medicine, Shahid Beheshti University of Medica, Sciences, Tehran, Islamic Republic of Iran.
  • Ardestani SK; Institute of Biochemistry and Biophysics, Tehran University, Tehran, Islamic Republic of Iran.
  • Gohari Moghadam K; Internal Medicine Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
  • Mirsharif ES; Immunoregulation Research Center, Shahed University, Tehran, Islamic Republic of Iran.
  • Dilmaghanian R; Immunoregulation Research Center, Shahed University, Tehran, Islamic Republic of Iran.
  • Fadaei A; Department of Pulmonology and Intensive Care Medicine, Shahid Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
  • Faghihzadeh S; Department of Biostatistics and Social Medicine, Zanjan University of Medical Sciences, Zanjan, Islamic Republic of Iran.
Toxicol Lett ; 312: 188-194, 2019 Sep 15.
Article en En | MEDLINE | ID: mdl-31095986
Sulfur mustard (SM) is a toxic agent that causes acute and long-term pulmonary complications. Recent evidence has shown the impact of SM on mesenchymal stem cells (MSCs). These cells have a critical role in repairing the damaged tissues. In this study, we evaluated the mobilization of MSCs in SM-exposed patients with long-term pulmonary complications. Fifty-nine SM-injured patients with prolonged pulmonary complications and 20 healthy individuals were included. Patients were classified based on taking drugs, having comorbidities, and severity of respiratory consequence. MSCs with phenotype of CD45-CD44+CD29+CD105+ were evaluated in peripheral blood using flow cytometry. Circulating MSCs were lower in SM-exposed patients compared to the control group (0.93 vs. 2.72 respectively, P = 0.005). No significant difference was observed in the MSC count between patients taking corticosteroids or antibiotics and those patients not taking them. Comorbidities like liver and kidney diseases had changed the count of MSCs in SM-exposed subjects. In addition, the frequency of MSCs did not show any association with the severity of long-term pulmonary complications. In conclusion, SM-exposure causes a decline in the frequency of circulating MSCs in survivors. The lower number of the peripheral MSC population in SM-exposed patients was not affected by taking corticosteroids or antibiotics, but comorbidities are probably involved in MSC frequency. The decreases observed in the number of circulating MSCs was not associated with the severity of the pulmonary complications; however, further studies in mustard lung models are required to demonstrate the therapeutic or pathologic role of MSCs in SM injuries.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sustancias para la Guerra Química / Células Madre Mesenquimatosas / Enfermedades Pulmonares / Gas Mostaza Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Toxicol Lett Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sustancias para la Guerra Química / Células Madre Mesenquimatosas / Enfermedades Pulmonares / Gas Mostaza Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Toxicol Lett Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos