Circulatory shock in pregnant sheep. IV. Fetal and neonatal circulatory responses to hypovolemia--influence of anesthesia.
Am J Obstet Gynecol
; 132(6): 658-66, 1978 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-31092
Hemodynamic responses to hypovolemia were investigated in unanesthetized, unstressed fetal lambs and in acute fetal and neonatal preparations. The unstressed fetus tolerated twice the amount of blood loss of the acutely studied fetus or newborn lamb and with a lesser hypotension. Hemodynamic behavior of the newborn lamb and fetus anesthetized with pentobarbital during hypovolemia was markedly different from that of the fetus studied under spinal anesthesia or chronically. Besides tolerating greater blood loss, the unstressed fetus reversed the state of hypovolemic shock rapidly as contrasted to the stressed fetus which was unable to do so even with total blood reinfusion. All animals exhibited bradycardia in response to hypovolemia. The following conclusions were drawn: (a) cardiovascular response to hypovolemia in the perinatal period depends on the initial status of the animal, (b) the fetus tolerates a greater degree of blood loss than a newborn or adult animal, and (c) anesthesia and stress of surgery modify considerably circulatory behavior during blood loss.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Complicaciones del Embarazo
/
Choque
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Feto
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Hemodinámica
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Anestesia
Límite:
Animals
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Pregnancy
Idioma:
En
Revista:
Am J Obstet Gynecol
Año:
1978
Tipo del documento:
Article
Pais de publicación:
Estados Unidos