Your browser doesn't support javascript.
loading
Habitual cigarette smoking raises pressor responses to spontaneous bursts of muscle sympathetic nerve activity.
Cui, Jian; Drew, Rachel C; Muller, Matthew D; Blaha, Cheryl; Gonzalez, Virginia; Sinoway, Lawrence I.
Afiliación
  • Cui J; Penn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
  • Drew RC; Penn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
  • Muller MD; Penn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
  • Blaha C; Penn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
  • Gonzalez V; Penn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
  • Sinoway LI; Penn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
Am J Physiol Regul Integr Comp Physiol ; 317(2): R280-R288, 2019 08 01.
Article en En | MEDLINE | ID: mdl-31091152
Smoking is a risk factor for cardiovascular diseases. Prior reports showed a transient increase in blood pressure (BP) following a spontaneous burst of muscle sympathetic nerve activity (MSNA). We hypothesized that this pressor response would be accentuated in smokers. Using signal-averaging techniques, we examined the BP (Finometer) response to MSNA in 18 otherwise healthy smokers and 42 healthy nonsmokers during resting conditions. The sensitivities of baroreflex control of MSNA and heart rate were also assessed. The mean resting MSNA, heart rate, and mean arterial pressure (MAP) were higher in smokers than nonsmokers. The MAP increase following a burst of MSNA was significantly greater in smokers than nonsmokers (Δ3.4 ± 0.3 vs. Δ1.6 ± 0.1 mmHg, P < 0.001). The baroreflex sensitivity (BRS) of burst incidence, burst area, or total activity was not different between the two groups. However, cardiac BRS was lower in smokers than nonsmokers (14.6 ± 1.7 vs. 24.6 ± 1.5 ms/mmHg, P < 0.001). Moreover, the MAP increase following a burst was negatively correlated with the cardiac BRS. These observations suggest that habitual smoking in otherwise healthy individuals raises the MAP increase following spontaneous MSNA and that the attenuated cardiac BRS in the smokers was a contributing factor. We speculate that the accentuated pressor increase in response to spontaneous MSNA may contribute to the elevated resting BP in the smokers.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Simpático / Presión Sanguínea / Fumar Cigarrillos / Hipertensión Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Am J Physiol Regul Integr Comp Physiol Asunto de la revista: FISIOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Simpático / Presión Sanguínea / Fumar Cigarrillos / Hipertensión Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Am J Physiol Regul Integr Comp Physiol Asunto de la revista: FISIOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos