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Combinatory effects of vaccinia virus VG9 and the STAT3 inhibitor Stattic on cancer therapy.
Yang, Runlin; Wang, Lizhen; Sheng, Jie; Huang, Qianhuan; Pan, Donghui; Xu, Yuping; Yan, Junjie; Wang, Xinyu; Dong, Ziyue; Yang, Min.
Afiliación
  • Yang R; Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, No. 20, Qianrong Road, Wuxi, 214063, China. yangrunlin@jsinm.org.
  • Wang L; Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, No. 20, Qianrong Road, Wuxi, 214063, China.
  • Sheng J; The First School of Clinical Medicine, Nanjing Medical University, Nanjing, 210029, China.
  • Huang Q; The First School of Clinical Medicine, Nanjing Medical University, Nanjing, 210029, China.
  • Pan D; Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, No. 20, Qianrong Road, Wuxi, 214063, China.
  • Xu Y; Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, No. 20, Qianrong Road, Wuxi, 214063, China.
  • Yan J; Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, No. 20, Qianrong Road, Wuxi, 214063, China.
  • Wang X; Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, No. 20, Qianrong Road, Wuxi, 214063, China.
  • Dong Z; Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, No. 20, Qianrong Road, Wuxi, 214063, China.
  • Yang M; Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, No. 20, Qianrong Road, Wuxi, 214063, China. yangmin@jsinm.org.
Arch Virol ; 164(7): 1805-1814, 2019 Jul.
Article en En | MEDLINE | ID: mdl-31087190
The recombinant vaccinia virus VG9 and the STAT3 inhibitor Stattic were combined to kill cancer cells via both oncolytic activity and inhibition of STAT3 phosphorylation in cells. The combinatory anti-tumour activity of these compounds was superior to the activity of VG9 or Stattic alone in vivo. The inhibition of tumour growth occurred via increased apoptosis and autophagy pathways. Furthermore, the combinatory anti-tumour activity was more efficient than that of VG9 or Stattic alone on xenografts, especially in nude mice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus Vaccinia / Óxidos S-Cíclicos / Proliferación Celular / Virus Oncolíticos / Factor de Transcripción STAT3 / Neoplasias / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Arch Virol Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Austria
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus Vaccinia / Óxidos S-Cíclicos / Proliferación Celular / Virus Oncolíticos / Factor de Transcripción STAT3 / Neoplasias / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Arch Virol Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Austria