Inhibition of ADP-ribosylation of histone H1 by analogs of diadenosine 5',5'''-p1,p4-tetraphosphate.
Mol Cell Biochem
; 74(1): 17-20, 1987 Mar.
Article
en En
| MEDLINE
| ID: mdl-3108656
The effects of analogs of diadenosine 5',5'''-p1,p4-tetraphosphate (Ap4A) were examined on the ADP-ribosylation reaction of histone H1 catalysed by purified bovine thymus poly(ADP-ribose)transferase. Among the compounds tested, epsilon Ap4A and ApCH2pppA were shown to be the most efficient inhibitors of the enzyme. From kinetic studies of their action, it appears that epsilon Ap4A and ApCH2pppA might be 'mixed type' inhibitors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Histonas
/
Nucleótidos de Adenina
/
Fosfatos de Dinucleósidos
/
Adenosina Difosfato Ribosa
/
Inhibidores de Poli(ADP-Ribosa) Polimerasas
Límite:
Animals
Idioma:
En
Revista:
Mol Cell Biochem
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Países Bajos