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Targeting HIF-1α in combination with PPARα activation and postnatal factors promotes the metabolic maturation of human induced pluripotent stem cell-derived cardiomyocytes.
Gentillon, Cinsley; Li, Dong; Duan, Meixue; Yu, Wen-Mei; Preininger, Marcela K; Jha, Rajneesh; Rampoldi, Antonio; Saraf, Anita; Gibson, Gregory C; Qu, Cheng-Kui; Brown, Lou Ann; Xu, Chunhui.
Afiliación
  • Gentillon C; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Li D; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Duan M; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
  • Yu WM; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Preininger MK; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
  • Jha R; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Rampoldi A; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Saraf A; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Gibson GC; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
  • Qu CK; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Brown LA; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Xu C; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. Electronic address: chunhui.xu@emory.edu.
J Mol Cell Cardiol ; 132: 120-135, 2019 07.
Article en En | MEDLINE | ID: mdl-31082397
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzamidas / Miocitos Cardíacos / PPAR alfa / Sinergismo Farmacológico / Subunidad alfa del Factor 1 Inducible por Hipoxia / Células Madre Pluripotentes Inducidas / Mitocondrias Límite: Humans Idioma: En Revista: J Mol Cell Cardiol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzamidas / Miocitos Cardíacos / PPAR alfa / Sinergismo Farmacológico / Subunidad alfa del Factor 1 Inducible por Hipoxia / Células Madre Pluripotentes Inducidas / Mitocondrias Límite: Humans Idioma: En Revista: J Mol Cell Cardiol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido