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Toxicological effects of Ramalina aspera (lichen) on Biomphalaria glabrata snails and Schistosoma mansoni cercariae.
Silva, Hianna Arely Milca Fagundes; Sá, José Luís Ferreira; Siqueira, Williams Nascimento de; Lima, Maíra de Vasconcelos; Martins, Mônica Cristina Barroso; Aires, André de Lima; Albuquerque, Mônica Camelo Pessoa de Azevedo; Falcão, Emerson Peter da Silva; Buril, Maria de Lourdes Lacerda; Pereira, Eugênia C; Melo, Ana Maria Mendonça de Albuquerque; Silva, Nicácio Henrique da.
Afiliación
  • Silva HAMF; Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, Brazil.
  • Sá JLF; Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, Brazil.
  • Siqueira WN; Departamento de Energia Nuclear, Universidade Federal de Pernambuco, Recife, PE, Brazil; Departamento de Biofísica e Radiobiologia, Universidade Federal de Pernambuco, Recife, PE, Brazil.
  • Lima MV; Departamento de Energia Nuclear, Universidade Federal de Pernambuco, Recife, PE, Brazil; Departamento de Biofísica e Radiobiologia, Universidade Federal de Pernambuco, Recife, PE, Brazil.
  • Martins MCB; Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, Brazil.
  • Aires AL; Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Recife, PE, Brazil.
  • Albuquerque MCPA; Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Recife, PE, Brazil.
  • Falcão EPDS; Centro Acadêmico de Vitória de Santo Antão, Universidade Federal de Pernambuco, Pernambuco, Brazil.
  • Buril MLL; Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, Brazil.
  • Pereira EC; Departamento de Ciências Geográficas, Universidade Federal de Pernambuco, Pernambuco, Brazil.
  • Melo AMMA; Departamento de Energia Nuclear, Universidade Federal de Pernambuco, Recife, PE, Brazil; Departamento de Biofísica e Radiobiologia, Universidade Federal de Pernambuco, Recife, PE, Brazil.
  • Silva NHD; Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, Brazil.
Acta Trop ; 196: 172-179, 2019 Aug.
Article en En | MEDLINE | ID: mdl-31082366
In this study, the molluscicidal activities against Biomphalaria glabrata and cercaricidal activities against Schistosoma mansoni of the ether extract of Ramalina aspera were evaluated. Additionally, toxicity parameters were evaluated at sublethal doses in terms of the influence of the extract on the fertility and fecundity of snails, as well as morphological alterations and quantification of their immunological cells. A test with Artemia salina was also carried out, in order to verify the environmental toxicity of the compound. The ether extract of R. aspera, in which divaricatic acid was identified as the major compound, demonstrated molluscicidal activity at low concentrations against both embryos (LC90 of 22.78, 24.23, 16.63 and 16.03 µg mL-1 for the gastrula, blastula, trochophore and veliger, respectively) and against adult snails (LC90 of 8.66 µg mL-1), after 24 h of exposure. At the sublethal doses, it was possible to observe a decrease in fecundity and quantitative and morphological changes in the defense cells of the exposed snails. In addition, the extract of R. aspera showed a cercaricidal effect on S. mansoni from the concentration of 5.0 µg mL-1, while showing low toxicity to Artemia salina. The ether extract of R. aspera demonstrated effective molluscicidal activity on embryos and adult snails of the species B. glabrata, cercariae of S. mansoni, and presenting low toxicity on Artemia salina. In this way, it could be considered a promising compound in the development of future molluscicidal and cercaricidal agents, thus helping to combat schistosomiasis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Schistosoma mansoni / Biomphalaria / Líquenes / Moluscocidas Límite: Animals Idioma: En Revista: Acta Trop Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Schistosoma mansoni / Biomphalaria / Líquenes / Moluscocidas Límite: Animals Idioma: En Revista: Acta Trop Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos