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Discriminating between neurofibromatosis-1 and typically developing children by means of multimodal MRI and multivariate analyses.
Nemmi, Federico; Cignetti, Fabien; Assaiante, Christine; Maziero, Stephanie; Audic, Fredrique; Péran, Patrice; Chaix, Yves.
Afiliación
  • Nemmi F; ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France.
  • Cignetti F; CNRS, LNC, Aix Marseille Université, Marseille, France.
  • Assaiante C; CNRS, Fédération 3C, Aix Marseille Université, Marseille, France.
  • Maziero S; CNRS, TIMC-IMAG, Université Grenoble Alpes, Grenoble, France.
  • Audic F; CNRS, LNC, Aix Marseille Université, Marseille, France.
  • Péran P; CNRS, Fédération 3C, Aix Marseille Université, Marseille, France.
  • Chaix Y; ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France.
Hum Brain Mapp ; 40(12): 3508-3521, 2019 08 15.
Article en En | MEDLINE | ID: mdl-31077476
Neurofibromatosis Type 1 leads to brain anomalies involving both gray and white matter. The extent and granularity of these anomalies, together with their possible impact on brain activity, is still unknown. In this multicentric cross-sectional study we submitted a sample of 42 typically developing and 38 neurofibromatosis-1 children to a multimodal MRI assessment including T1, diffusion weighted and resting state functional sequences. We used a pipeline involving several features selection steps coupled with multivariate statistical analysis (supporting vector machine) to discriminate between the two groups while having interpretable models. We used MRI indexes measuring macro (gray matter volume) and microstructural (fractional anisotropy, mean diffusivity) characteristics of the brain, as well as indexes of brain activity (fractional amplitude of low frequency fluctuations) and connectivity (local and global correlation) at rest. We found that structural indexes could discriminate between the two groups, with the mean diffusivity leading to performance as high as the combination of all structural indexes combined (accuracy = 0.86), while functional indexes had worse performances. The MRI signature of NF1 brain pathology is a combination of gray and white matter abnormalities, as measured with gray matter volume, fractional anisotropy, and mean diffusivity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Neurofibromatosis 1 / Sustancia Gris / Sustancia Blanca Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2019 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Neurofibromatosis 1 / Sustancia Gris / Sustancia Blanca Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2019 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos