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Diabetes-mediated IL-17A enhances retinal inflammation, oxidative stress, and vascular permeability.
Sigurdardottir, Sigrun; Zapadka, Thomas E; Lindstrom, Sarah I; Liu, Haitao; Taylor, Brooklyn E; Lee, Chieh A; Kern, Timothy S; Taylor, Patricia R.
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  • Sigurdardottir S; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, School of Medicine, Cleveland, OH, United States.
  • Zapadka TE; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, School of Medicine, Cleveland, OH, United States.
  • Lindstrom SI; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, School of Medicine, Cleveland, OH, United States.
  • Liu H; Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, OH, United States.
  • Taylor BE; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, School of Medicine, Cleveland, OH, United States.
  • Lee CA; Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, OH, United States.
  • Kern TS; Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, OH, United States; Louis Stokes VA Medical Center, Cleveland, OH, United States.
  • Taylor PR; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, School of Medicine, Cleveland, OH, United States; Louis Stokes VA Medical Center, Cleveland, OH, United States. Electronic address: patricia.r.taylor@case.edu.
Cell Immunol ; 341: 103921, 2019 07.
Article en En | MEDLINE | ID: mdl-31076079
Diabetic retinopathy is a prevailing diabetes complication, and one of the leading causes of blindness worldwide. IL-17A is a cytokine involved in the onset of diabetic complications. In the current study, we examined the role of IL-17A in the development of retinal inflammation and long-term vascular pathology in diabetic mice. We found IL-17A expressing T cells and neutrophils in the retinal vasculature. Further, the IL-17A receptor was expressed on Muller glia, retinal endothelial cells, and photoreceptors. Finally, diabetes-mediated retinal inflammation, oxidative stress, and vascular leakage were all significantly lower in IL-17A-/- mice. These are all clinically meaningful abnormalities that characterize the onset of diabetic retinopathy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Permeabilidad Capilar / Interleucina-17 / Células Endoteliales / Diabetes Mellitus Experimental / Retinopatía Diabética / Células Ependimogliales Límite: Animals Idioma: En Revista: Cell Immunol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Permeabilidad Capilar / Interleucina-17 / Células Endoteliales / Diabetes Mellitus Experimental / Retinopatía Diabética / Células Ependimogliales Límite: Animals Idioma: En Revista: Cell Immunol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos