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3-Methyladenine alleviates excessive iodine-induced cognitive impairment via suppression of autophagy in rat hippocampus.
Zhao, Liang; Zhang, Bin; Cui, Yushan; Hou, Changchun; Zeng, Qiang; Gao, Tongning; Zhang, Zushan; Yu, Jingwen; Wang, Yang; Wang, Aiguo; Liu, Hongliang.
Afiliación
  • Zhao L; Institute of Environment and Health, Tianjin Centers for Disease Control and Prevention, Tianjin, China.
  • Zhang B; Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, China.
  • Cui Y; Institute of Environment and Health, Tianjin Centers for Disease Control and Prevention, Tianjin, China.
  • Hou C; Institute of Environment and Health, Tianjin Centers for Disease Control and Prevention, Tianjin, China.
  • Zeng Q; Institute of Occupational Disease Control and Prevention, Tianjin Centers for Disease Control and Prevention, Tianjin, China.
  • Gao T; Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, China.
  • Zhang Z; Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, China.
  • Yu J; Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, China.
  • Wang Y; Institute of Environment and Health, Tianjin Centers for Disease Control and Prevention, Tianjin, China.
  • Wang A; Department of Environmental Health and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, Wuhan, China.
  • Liu H; Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, China.
Environ Toxicol ; 34(8): 912-920, 2019 Aug.
Article en En | MEDLINE | ID: mdl-31074208
Drinking water with high levels of iodine has been identified as the key contributor to iodine excess, but the mechanisms of neurotoxicity induced by excessive iodine remain elusive. The present study aimed to explore the role of autophagy in the neurotoxic effect induced by excessive iodine in vivo. The Morris water maze test results demonstrated that excessive iodine impaired the learning and memory capabilities of rats, which were associated with marked body weight and brain weight abnormalities. In addition, iodine treatment increased malondialdehyde accumulation, decreased superoxide dismutase activity and glutathione (GSH) level, and enhanced levels of autophagy markers in the hippocampus. Notably, inhibition of autophagy with 3-methyladenine (3-MA) could significantly alleviate excessive iodine-induced cognitive impairment. These data imply that autophagy is involved in the cognitive impairment elicited by excessive iodine as a pathway of cell death, and inhibition of autophagy via 3-MA may significantly alleviate the above damage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Adenina / Aprendizaje por Laberinto / Hipocampo / Yodo Límite: Animals Idioma: En Revista: Environ Toxicol Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Adenina / Aprendizaje por Laberinto / Hipocampo / Yodo Límite: Animals Idioma: En Revista: Environ Toxicol Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos