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The efficacy of local anesthetics in pain relief during colposcopic-guided biopsy: A systematic review and meta-analysis of randomized controlled trials.
Mattar, Omar M; Samy, Ahmed; Shehata, Mohamed; Ibrahim, Ahmed M; Abdelaziz, Ahmed; Abdelazeim, Nesrine; Elzemrany, Amal A; Kasem, Shiref A; Ros, Mohamed Hassan; Hamad, Linda Y; Taher, Ayman; El-Sharkawy, Mohamed; Mahmoud, Mostafa; Abbas, Ahmed M.
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  • Mattar OM; Kasr Al-Ainy Faculty of Medicine, Cairo University, Egypt; Medical Research Education and Practice Association (MREP), Cairo, Egypt.
  • Samy A; Department of Obstetrics and Gynaecology, Faculty of Medicine, Cairo University, Egypt.
  • Shehata M; Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Ibrahim AM; Medical Research Education and Practice Association (MREP), Cairo, Egypt; Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
  • Abdelaziz A; Medical Research Education and Practice Association (MREP), Cairo, Egypt; Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
  • Abdelazeim N; Kasr Al-Ainy Faculty of Medicine, Cairo University, Egypt.
  • Elzemrany AA; Medical Research Education and Practice Association (MREP), Cairo, Egypt; Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
  • Kasem SA; Medical Research Education and Practice Association (MREP), Cairo, Egypt; Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
  • Ros MH; Medical Research Education and Practice Association (MREP), Cairo, Egypt; Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Hamad LY; Medical Research Education and Practice Association (MREP), Cairo, Egypt; Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Taher A; Department of Obstetrics and Gynaecology, Faculty of Medicine, Cairo University, Egypt.
  • El-Sharkawy M; Department of Obstetrics and Gynaecology, Faculty of Medicine, Cairo University, Egypt.
  • Mahmoud M; Department of Obstetrics and Gynaecology, Faculty of Medicine, Cairo University, Egypt.
  • Abbas AM; Department of Obstetrics and Gynaecology, Faculty of Medicine, Assiut University, Egypt. Electronic address: ahmedabbas@aun.edu.eg.
Eur J Obstet Gynecol Reprod Biol ; 237: 189-197, 2019 Jun.
Article en En | MEDLINE | ID: mdl-31071652
BACKGROUND: Colposcopy is an office gynecological procedure used for cervical evaluation in patients with abnormal cervical cytology. It is considered an important tool for early detection of cases of cervical cancer. OBJECTIVE: To evaluate the evidence from published randomized clinical trials (RCTs) about the efficacy of local anesthetics in pain relief during colposcopic-guided biopsy. DATA SOURCES: Several electronic databases included MEDLINE, EMBASE, Cochrane Library, ISI and Scopus were searched using the relevant MeSH terms. METHODS OF STUDY SELECTION: All RCTs assessing the effect of local anesthetics in relieving pain during colposcopy were considered for this meta-analysis. There were 1339 studies identified of which 11 studies deemed eligible for this review. We performed quality and risk of bias assessment for all included studies. DATA EXTRACTION: Three researchers independently extracted the data from the individual articles and entered it into RevMan software. The extracted outcomes included pain scores and the duration of the procedure. RESULTS: Eleven RCTs were included. Local anesthesia (LA) was associated with higher pain at speculum insertion than control (SMD = 0.23, 95% CI [0.03, 0.43]). While, LA significantly reduced biopsy pain than control (SMD= -0.57, 95% CI [-0.94, -0.20]). The overall pooled estimate showed no significant difference between LA and control regarding postprocedural pain, pain on endocervical curettage, pain expectancy, and overall pain scores. CONCLUSIONS: This meta-analysis suggests that local anesthetics are effective in pain relief during a colposcopic-guided biopsy; however there is no strong evidence to recommend its use in current practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biopsia / Colposcopía / Dolor Asociado a Procedimientos Médicos / Anestésicos Locales Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Screening_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Eur J Obstet Gynecol Reprod Biol Año: 2019 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biopsia / Colposcopía / Dolor Asociado a Procedimientos Médicos / Anestésicos Locales Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Screening_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Eur J Obstet Gynecol Reprod Biol Año: 2019 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Irlanda