Effects of carotid denervation on interactions between lung inflation and PaCO2 in modulating phrenic activity.
Respir Physiol
; 67(3): 367-78, 1987 Mar.
Article
en En
| MEDLINE
| ID: mdl-3107099
Hypercapnia attenuates the effects of static airway pressure (Paw) on phrenic burst frequency (f) and the expiratory duration. We examined the role of carotid chemoreceptors in this response using an experimental preparation that allowed independent control of lung inflation and CO2 reflexes. Experiments were conducted in intact (n = 6) and carotid denervated (CBX; n = 12) chloralose/urethane anesthetized dogs. Integrated phrenic amplitude (Phr), f, and the inspiratory (TI) and expiratory durations (TE) were measured as a function of Paw (2-12 cm H2O) at levels of PaCO2 between 30 and 80 mm Hg. In intact dogs: (1) f decreased as Paw increased, and elevated PaCO2 decreased the slope of this relationship; (2) neither PaCO2 nor Paw affected TI; and (3) TE increased hyperbolically with Paw, and elevated PaCO2 attenuated this relationship. In CBX dogs: (1) f decreased as Paw increased, but this relationship was not affected by PaCO2; (2) TI increased as PaCO2 increased but was unaffected by Paw; and (3) TE increased as Paw increased but was unaffected by PaCO2. The results indicate that carotid chemoreceptors are necessary in the mechanism whereby hypercapnia attenuates the effects of Paw on f and TE. Furthermore, carotid denervation reveals an effect of hypercapnia on TI, an effect that is not evident in dogs with functional carotid chemoreceptors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nervio Frénico
/
Respiración
/
Dióxido de Carbono
/
Células Quimiorreceptoras
Límite:
Animals
Idioma:
En
Revista:
Respir Physiol
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Países Bajos