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d- chiro-Inositol Ameliorates High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance via PKCε-PI3K/AKT Pathway.
Cheng, Feier; Han, Lin; Xiao, Yao; Pan, Chuanying; Li, Yunlong; Ge, Xinhui; Zhang, Yao; Yan, Shaoqing; Wang, Min.
Afiliación
  • Cheng F; College of Food Science and Engineering , Northwest A&F University , Yangling , Shaanxi 712100 , People's Republic of China.
  • Han L; College of Food Science and Engineering , Northwest A&F University , Yangling , Shaanxi 712100 , People's Republic of China.
  • Xiao Y; College of Food Science and Engineering , Northwest A&F University , Yangling , Shaanxi 712100 , People's Republic of China.
  • Pan C; College of Animal Science and Technology , Northwest A&F University , Yangling , Shaanxi 712100 , People's Republic of China.
  • Li Y; Institute of Agricultural Products Processing , Shanxi Academy of Agriculture Sciences , Taiyuan 030031 , People's Republic of China.
  • Ge X; College of Food Science and Engineering , Northwest A&F University , Yangling , Shaanxi 712100 , People's Republic of China.
  • Zhang Y; College of Food Science and Engineering , Northwest A&F University , Yangling , Shaanxi 712100 , People's Republic of China.
  • Yan S; College of Food Science and Engineering , Northwest A&F University , Yangling , Shaanxi 712100 , People's Republic of China.
  • Wang M; College of Food Science and Engineering , Northwest A&F University , Yangling , Shaanxi 712100 , People's Republic of China.
J Agric Food Chem ; 67(21): 5957-5967, 2019 May 29.
Article en En | MEDLINE | ID: mdl-31066268
d- chiro-Inositol (DCI) is a biologically active component found in tartary buckwheat, which can reduce hyperglycemia and ameliorate insulin resistance. However, the mechanism underlying the antidiabetic effects of DCI remains largely unclear. This study investigated the effects and underlying molecular mechanisms of DCI on hepatic gluconeogenesis in mice fed a high fat diet and saturated palmitic acid-treated hepatocytes. DCI attenuated free fatty acid uptake by the liver via lipid trafficking inhibition, reduced diacylglycerol deposition, and hepatic PKCε translocation. Thus, DCI could improve insulin sensitivity by suppressing hepatic gluconeogenesis. Subsequent analyses revealed that DCI decreased hepatic glucose output and the expression levels of PEPCK and G6 Pase in insulin resistant mice through PKCε-IRS/PI3K/AKT signaling pathway. Likewise, such effects of DCI were confirmed in HepG2 cells with palmitate-induced insulin resistance. These findings indicate a novel pathway by which DCI prevents hepatic gluconeogenesis, reduces lipid deposition, and ameliorates insulin resistance via regulation of PKCε-PI3K/AKT axis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Fosfatidilinositol 3-Quinasas / Proteína Quinasa C-epsilon / Proteínas Proto-Oncogénicas c-akt / Hígado Graso / Inositol Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: J Agric Food Chem Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Fosfatidilinositol 3-Quinasas / Proteína Quinasa C-epsilon / Proteínas Proto-Oncogénicas c-akt / Hígado Graso / Inositol Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: J Agric Food Chem Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos