Identification of a rabbit class I-like thymocyte-specific antigen.
J Immunol
; 138(10): 3352-9, 1987 May 15.
Article
en En
| MEDLINE
| ID: mdl-3106481
The availability of a monoclonal antibody, 5E2, has made it possible to characterize a new class I-like thymocyte-specific antigen in the rabbit. Flow cytometry and cyto-fluorescent microscopy show that approximately 70 to 80% of the cells reacting with 5E2 are located throughout the thymic cortex. Structural studies reveal that the cell surface molecule recognized by 5E2 is a non-covalently associated heterodimer consisting of a 45,000 dalton glycoprotein and a low m.w. beta-2-microglobulin protein. Certain properties of the 5E2 antigen were similar to the murine TL and human T6 antigens. Therefore we have tentatively assigned to the 5E2 antigen the designation R-Ta on the premise that the structural gene(s) encoding this molecule will be associated with the rabbit major histocompatibility complex.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conejos
/
Linfocitos T
/
Microglobulina beta-2
/
Antígenos de Superficie
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Immunol
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Estados Unidos